A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans

© 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhi...

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Main Authors:	Onozawa T., Kitajima M., Kogure N., Peerakam N., Santiarworn D., Takayama H.
Format:	Journal
Published:	2017
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40260
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-40260
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spelling	th-cmuir.6653943832-402602017-09-28T04:08:35Z A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans Onozawa T. Kitajima M. Kogure N. Peerakam N. Santiarworn D. Takayama H. © 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhiza nutans (Rubiaceae). Compound 1 is a tetrapeptide possessing a 14-membered paracyclophane ring and a novel N,N,N-trimethyltyrosine residue in the side chain. The stereochemistry at the aryl-alkyl ether bond was different from that of other known 14-membered paracyclophanes. The structure of 2 was established by spectroscopic analysis and semisynthesis. 2017-09-28T04:08:35Z 2017-09-28T04:08:35Z 7 Journal 01633864 2-s2.0-85026509664 10.1021/acs.jnatprod.7b00290 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40260
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
description	© 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhiza nutans (Rubiaceae). Compound 1 is a tetrapeptide possessing a 14-membered paracyclophane ring and a novel N,N,N-trimethyltyrosine residue in the side chain. The stereochemistry at the aryl-alkyl ether bond was different from that of other known 14-membered paracyclophanes. The structure of 2 was established by spectroscopic analysis and semisynthesis.
format	Journal
author	Onozawa T. Kitajima M. Kogure N. Peerakam N. Santiarworn D. Takayama H.
spellingShingle	Onozawa T. Kitajima M. Kogure N. Peerakam N. Santiarworn D. Takayama H. A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
author_facet	Onozawa T. Kitajima M. Kogure N. Peerakam N. Santiarworn D. Takayama H.
author_sort	Onozawa T.
title	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_short	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_full	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_fullStr	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_full_unstemmed	A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
title_sort	cyclopeptide and a tetrahydroisoquinoline alkaloid from ophiorrhiza nutans
publishDate	2017
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026509664&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40260
_version_	1681421776961142784

A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans

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