Effects of hydrophilic compounds in purple rice husk on AFB<inf>1</inf>-induced mutagenesis

© 2017, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media B.V. Rice husk has been shown to possess cancer chemopreventive activity. This study focused on mutagenicity and antimutagenicity of the crude acidified methanolic extract of purple rice husk and it...

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Main Authors: Nilnumkhum A., Punvittayagul C., Chariyakornkul A., Wongpoomchai R.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021274190&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/40391
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-403912017-09-28T04:09:15Z Effects of hydrophilic compounds in purple rice husk on AFB<inf>1</inf>-induced mutagenesis Nilnumkhum A. Punvittayagul C. Chariyakornkul A. Wongpoomchai R. © 2017, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media B.V. Rice husk has been shown to possess cancer chemopreventive activity. This study focused on mutagenicity and antimutagenicity of the crude acidified methanolic extract of purple rice husk and its solvent- partitioned fractions using a Salmonella mutation assay and rat liver micronucleus test. The purple rice husk extracts were not mutagenic in S. typhimurium strain TA98, but were mutagenic in TA100 (crude extract and its hydrophilic fractions). There was no significant mutagenicity of purple rice husk extracts in rat liver. The rice husks possessed antimutagenicity against AFB 1 -induced mutagenesis in both bacterial and animal models. The dichloromethane-partitioned fraction (DPF) showed the highest antimutagenicity. Vanillic acid, a major phenolic compound found in DPF, exhibited antimutagenicity against AFB 1 in both bacterial and rat models. The inhibitory mechanism was associated with the induction of detoxifying enzymes in AFB 1 metabolism of rat liver. These findings suggested that vanillic acid may be a principal antimutagenic compound in purple rice husk. 2017-09-28T04:09:15Z 2017-09-28T04:09:15Z 2 Journal 1738642X 2-s2.0-85021274190 10.1007/s13273-017-0018-5 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021274190&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40391
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2017, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media B.V. Rice husk has been shown to possess cancer chemopreventive activity. This study focused on mutagenicity and antimutagenicity of the crude acidified methanolic extract of purple rice husk and its solvent- partitioned fractions using a Salmonella mutation assay and rat liver micronucleus test. The purple rice husk extracts were not mutagenic in S. typhimurium strain TA98, but were mutagenic in TA100 (crude extract and its hydrophilic fractions). There was no significant mutagenicity of purple rice husk extracts in rat liver. The rice husks possessed antimutagenicity against AFB 1 -induced mutagenesis in both bacterial and animal models. The dichloromethane-partitioned fraction (DPF) showed the highest antimutagenicity. Vanillic acid, a major phenolic compound found in DPF, exhibited antimutagenicity against AFB 1 in both bacterial and rat models. The inhibitory mechanism was associated with the induction of detoxifying enzymes in AFB 1 metabolism of rat liver. These findings suggested that vanillic acid may be a principal antimutagenic compound in purple rice husk.
format Journal
author Nilnumkhum A.
Punvittayagul C.
Chariyakornkul A.
Wongpoomchai R.
spellingShingle Nilnumkhum A.
Punvittayagul C.
Chariyakornkul A.
Wongpoomchai R.
Effects of hydrophilic compounds in purple rice husk on AFB<inf>1</inf>-induced mutagenesis
author_facet Nilnumkhum A.
Punvittayagul C.
Chariyakornkul A.
Wongpoomchai R.
author_sort Nilnumkhum A.
title Effects of hydrophilic compounds in purple rice husk on AFB<inf>1</inf>-induced mutagenesis
title_short Effects of hydrophilic compounds in purple rice husk on AFB<inf>1</inf>-induced mutagenesis
title_full Effects of hydrophilic compounds in purple rice husk on AFB<inf>1</inf>-induced mutagenesis
title_fullStr Effects of hydrophilic compounds in purple rice husk on AFB<inf>1</inf>-induced mutagenesis
title_full_unstemmed Effects of hydrophilic compounds in purple rice husk on AFB<inf>1</inf>-induced mutagenesis
title_sort effects of hydrophilic compounds in purple rice husk on afb<inf>1</inf>-induced mutagenesis
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021274190&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/40391
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