Targeted endometrial cancer therapy as a future prospect

Among female-specific cancers worldwide, endometrial cancer is the third most common after breast cancer and cervical cancer. In addition, it is the most common gynecological cancer in the USA and Europe. The incidence of this disease appears to be increasing. The cause of this increase is multifact...

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Main Authors: Thanapprapasr D., Cheewakriangkrai C., Likittanasombut P., Thanapprapasr K., Mutch D.G.
Format: Review
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84874892992&partnerID=40&md5=532473aedeebf668fc12f83959aaccd7
http://www.ncbi.nlm.nih.gov/pubmed/23477324
http://cmuir.cmu.ac.th/handle/6653943832/4054
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-40542014-08-30T02:35:37Z Targeted endometrial cancer therapy as a future prospect Thanapprapasr D. Cheewakriangkrai C. Likittanasombut P. Thanapprapasr K. Mutch D.G. Among female-specific cancers worldwide, endometrial cancer is the third most common after breast cancer and cervical cancer. In addition, it is the most common gynecological cancer in the USA and Europe. The incidence of this disease appears to be increasing. The cause of this increase is multifactorial, but a few possible factors involved are increasing obesity, an aging population leading to more postmenopausal women and greater tamoxifen use. Surgery is generally the primary treatment of this disease and postoperative radiation therapy in some patients with high or intermediate risk may prevent locoregional recurrences. Adjuvant chemotherapy improves progression-free survival in advanced or recurrent cancer. However, overall survival in patients with advanced disease is poor. Hence, better therapy is needed and targeted molecular therapies are emerging as possible treatment candidates. These include molecules that target VEGF, mTOR, tyrosine kinases, human EGF receptors and FGF receptors. Therapies targeting specific molecular features should be evaluated in future strategies in the treatment of endometrial cancer. © 2013 Future Medicine Ltd. 2014-08-30T02:35:37Z 2014-08-30T02:35:37Z 2013 Review 17455057 10.2217/whe.13.4 23477324 http://www.scopus.com/inward/record.url?eid=2-s2.0-84874892992&partnerID=40&md5=532473aedeebf668fc12f83959aaccd7 http://www.ncbi.nlm.nih.gov/pubmed/23477324 http://cmuir.cmu.ac.th/handle/6653943832/4054 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Among female-specific cancers worldwide, endometrial cancer is the third most common after breast cancer and cervical cancer. In addition, it is the most common gynecological cancer in the USA and Europe. The incidence of this disease appears to be increasing. The cause of this increase is multifactorial, but a few possible factors involved are increasing obesity, an aging population leading to more postmenopausal women and greater tamoxifen use. Surgery is generally the primary treatment of this disease and postoperative radiation therapy in some patients with high or intermediate risk may prevent locoregional recurrences. Adjuvant chemotherapy improves progression-free survival in advanced or recurrent cancer. However, overall survival in patients with advanced disease is poor. Hence, better therapy is needed and targeted molecular therapies are emerging as possible treatment candidates. These include molecules that target VEGF, mTOR, tyrosine kinases, human EGF receptors and FGF receptors. Therapies targeting specific molecular features should be evaluated in future strategies in the treatment of endometrial cancer. © 2013 Future Medicine Ltd.
format Review
author Thanapprapasr D.
Cheewakriangkrai C.
Likittanasombut P.
Thanapprapasr K.
Mutch D.G.
spellingShingle Thanapprapasr D.
Cheewakriangkrai C.
Likittanasombut P.
Thanapprapasr K.
Mutch D.G.
Targeted endometrial cancer therapy as a future prospect
author_facet Thanapprapasr D.
Cheewakriangkrai C.
Likittanasombut P.
Thanapprapasr K.
Mutch D.G.
author_sort Thanapprapasr D.
title Targeted endometrial cancer therapy as a future prospect
title_short Targeted endometrial cancer therapy as a future prospect
title_full Targeted endometrial cancer therapy as a future prospect
title_fullStr Targeted endometrial cancer therapy as a future prospect
title_full_unstemmed Targeted endometrial cancer therapy as a future prospect
title_sort targeted endometrial cancer therapy as a future prospect
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84874892992&partnerID=40&md5=532473aedeebf668fc12f83959aaccd7
http://www.ncbi.nlm.nih.gov/pubmed/23477324
http://cmuir.cmu.ac.th/handle/6653943832/4054
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