Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus

Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus

© 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectrosco...

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Main Authors: Boonyaketgoson S., Rukachaisirikul V., Phongpaichit S., Trisuwan K.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/40550
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-405502017-09-28T04:10:08Z Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus Boonyaketgoson S. Rukachaisirikul V. Phongpaichit S. Trisuwan K. © 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. The cytotoxic activity of selected compounds against KB, MCF-7 and NCI-H187 cell lines was evaluated. Heterophyllene C (3) exhibited cytotoxicity against the MCF-7 cell line with an IC 50 value of 12.56 μM. Additionally, the known compounds norartocarpin and artocarpin showed cytotoxic activity against MCF-7 and KB cell lines with IC 50 values of 10.04 and 13.57 μM, respectively. Both compounds also displayed cytotoxicity against the NCI-H187 cell line with values of 14.78 and 14.21 μM, respectively. 2017-09-28T04:10:08Z 2017-09-28T04:10:08Z 16 Journal 00404039 2-s2.0-85015307707 10.1016/j.tetlet.2017.03.020 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40550
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. The cytotoxic activity of selected compounds against KB, MCF-7 and NCI-H187 cell lines was evaluated. Heterophyllene C (3) exhibited cytotoxicity against the MCF-7 cell line with an IC 50 value of 12.56 μM. Additionally, the known compounds norartocarpin and artocarpin showed cytotoxic activity against MCF-7 and KB cell lines with IC 50 values of 10.04 and 13.57 μM, respectively. Both compounds also displayed cytotoxicity against the NCI-H187 cell line with values of 14.78 and 14.21 μM, respectively.
format Journal
author Boonyaketgoson S.
Rukachaisirikul V.
Phongpaichit S.
Trisuwan K.
spellingShingle Boonyaketgoson S.
Rukachaisirikul V.
Phongpaichit S.
Trisuwan K.
Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
author_facet Boonyaketgoson S.
Rukachaisirikul V.
Phongpaichit S.
Trisuwan K.
author_sort Boonyaketgoson S.
title Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_short Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_full Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_fullStr Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_full_unstemmed Cytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllus
title_sort cytotoxic arylbenzofuran and stilbene derivatives from the twigs of artocarpus heterophyllus
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015307707&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/40550
_version_ 1681421838311227392

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