Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand
© 2016 Cambridge University Press. Aim: To report of long-term results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic radiation therapy (WPRT) for cervical carcinoma. Materials and Methods: In total, 52 patients with locally advanced cervical carcinoma were...
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th-cmuir.6653943832-407012017-09-28T04:11:01Z Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand Tharavichitkul E. Chakrabandhu S. Klunklin P. Onchan W. Jia-Mahasap B. Janla-Or S. Tippanya D. Nobnop W. Wanwilairat S. Pukanhaphan N. Galalae R. Chitapanarux I. © 2016 Cambridge University Press. Aim: To report of long-term results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic radiation therapy (WPRT) for cervical carcinoma. Materials and Methods: In total, 52 patients with locally advanced cervical carcinoma were enrolled into the study. WPRT was used to treat the clinical target volume (CTV) with a dose of 45-50·4 Gy in 23-28 fractions. IGBT using computed tomography was performed at the dose of 6·5-7 Gy×4 fractions to the minimum dose covering 90% of target volume (D90) of high-risk clinical target volume (HR-CTV). Results: The mean cumulative dose in equivalent doses of 2 Gy for the D90 of HR-CTV, dose at 2% at refereed volume (D2cc) of bladder, D2cc of rectum and D2cc of sigmoid colon were 92·4, 87·9, 69·6, and 72 Gy, respectively. At the median follow-up time of 61 months, the 5-year local control, disease-free survival, and overall survival rates were 96·2, 75 and 84·6% respectively. Two patients (3·8%) developed grade 3-4 gastrointestinal and two patients (3·8%) developed grade 3-4 genitourinal toxicities. Conclusion: The combination of WPRT plus IGBT showed very promising long-term results with excellent local control and toxicity profiles. 2017-09-28T04:11:01Z 2017-09-28T04:11:01Z 1 Journal 14603969 2-s2.0-85006750229 10.1017/S1460396916000510 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006750229&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40701 |
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© 2016 Cambridge University Press. Aim: To report of long-term results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic radiation therapy (WPRT) for cervical carcinoma. Materials and Methods: In total, 52 patients with locally advanced cervical carcinoma were enrolled into the study. WPRT was used to treat the clinical target volume (CTV) with a dose of 45-50·4 Gy in 23-28 fractions. IGBT using computed tomography was performed at the dose of 6·5-7 Gy×4 fractions to the minimum dose covering 90% of target volume (D90) of high-risk clinical target volume (HR-CTV). Results: The mean cumulative dose in equivalent doses of 2 Gy for the D90 of HR-CTV, dose at 2% at refereed volume (D2cc) of bladder, D2cc of rectum and D2cc of sigmoid colon were 92·4, 87·9, 69·6, and 72 Gy, respectively. At the median follow-up time of 61 months, the 5-year local control, disease-free survival, and overall survival rates were 96·2, 75 and 84·6% respectively. Two patients (3·8%) developed grade 3-4 gastrointestinal and two patients (3·8%) developed grade 3-4 genitourinal toxicities. Conclusion: The combination of WPRT plus IGBT showed very promising long-term results with excellent local control and toxicity profiles. |
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Tharavichitkul E. Chakrabandhu S. Klunklin P. Onchan W. Jia-Mahasap B. Janla-Or S. Tippanya D. Nobnop W. Wanwilairat S. Pukanhaphan N. Galalae R. Chitapanarux I. |
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Tharavichitkul E. Chakrabandhu S. Klunklin P. Onchan W. Jia-Mahasap B. Janla-Or S. Tippanya D. Nobnop W. Wanwilairat S. Pukanhaphan N. Galalae R. Chitapanarux I. Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand |
author_facet |
Tharavichitkul E. Chakrabandhu S. Klunklin P. Onchan W. Jia-Mahasap B. Janla-Or S. Tippanya D. Nobnop W. Wanwilairat S. Pukanhaphan N. Galalae R. Chitapanarux I. |
author_sort |
Tharavichitkul E. |
title |
Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand |
title_short |
Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand |
title_full |
Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand |
title_fullStr |
Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand |
title_full_unstemmed |
Five-year results for image-guided brachytherapy (IGBT) for cervical carcinoma: A report from single institute of Thailand |
title_sort |
five-year results for image-guided brachytherapy (igbt) for cervical carcinoma: a report from single institute of thailand |
publishDate |
2017 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006750229&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40701 |
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1681421865975808000 |