Inhibition of P-glycoprotein mediated multidrug resistance by stemofoline derivatives

• Main Authors: Umsumarng S., Pintha K., Pitchakarn P., Sastraruji K., Sastraruji T., Ung A.T., Jatisatienr A., Pyne S.G., Limtrakul P.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84876493908&partnerID=40&md5=e7b67aa2431b15a73d0d01511543abce; http://cmuir.cmu.ac.th/handle/6653943832/4083
• Institution: Chiang Mai University

Resistance to chemotherapy in cancer patients has been correlated to the overexpression of the ATPbinding cassette (ABC) drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cancer cells. We examined the mutidrug resistance reversing property of stemofol...