Quality of life in cervical dystonia after treatment with botulinum toxin a: A 24-week prospective study

© 2017 Kongsaengdao et al. Objective: This study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients. Materials and methods: A 24-week prospective study...

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Main Authors: Kongsaengdao S., Maneeton B., Maneeton N.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010280708&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/40837
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-408372017-09-28T04:11:43Z Quality of life in cervical dystonia after treatment with botulinum toxin a: A 24-week prospective study Kongsaengdao S. Maneeton B. Maneeton N. © 2017 Kongsaengdao et al. Objective: This study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients. Materials and methods: A 24-week prospective study comparing HRQoL of Thai CD patients before and after multiple injections of botulinum toxin A at 3-month intervals was performed. Disease-specific HRQoL was assessed by using the Cervical Dystonia Impact Profile-58 questionnaire (CDIP-58) and the Craniocervical Dystonia Questionnaire-24 (CDQ-24). General HRQoL was assessed by using the Medical Outcomes’ 36-Item Short Form Health Survey (SF-36) and the EuroQoL 5-dimension questionnaire (EQ-5D). All the assessments were performed before and after the 24-week treatment period. Results: A total of 20 CD patients were enrolled in this study from April to December 2011. CDIP-58 and CDQ-24 scores, which assess disease-specific HRQoL, showed a significant improvement after 24 weeks of treatment by botulinum toxin A (P < 0.001). However, EQ-5D and SF-36 scores, which assess general HRQoL, showed no significant improvement after the treatment (P > 0.05). Conclusion: CD patients’ disease-specific HRQoL improved after being treated with multiple botulinum toxin A injections. However, general HRQoL was not improved. 2017-09-28T04:11:43Z 2017-09-28T04:11:43Z Journal 11766328 2-s2.0-85010280708 10.2147/NDT.S116325 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010280708&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40837
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2017 Kongsaengdao et al. Objective: This study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients. Materials and methods: A 24-week prospective study comparing HRQoL of Thai CD patients before and after multiple injections of botulinum toxin A at 3-month intervals was performed. Disease-specific HRQoL was assessed by using the Cervical Dystonia Impact Profile-58 questionnaire (CDIP-58) and the Craniocervical Dystonia Questionnaire-24 (CDQ-24). General HRQoL was assessed by using the Medical Outcomes’ 36-Item Short Form Health Survey (SF-36) and the EuroQoL 5-dimension questionnaire (EQ-5D). All the assessments were performed before and after the 24-week treatment period. Results: A total of 20 CD patients were enrolled in this study from April to December 2011. CDIP-58 and CDQ-24 scores, which assess disease-specific HRQoL, showed a significant improvement after 24 weeks of treatment by botulinum toxin A (P < 0.001). However, EQ-5D and SF-36 scores, which assess general HRQoL, showed no significant improvement after the treatment (P > 0.05). Conclusion: CD patients’ disease-specific HRQoL improved after being treated with multiple botulinum toxin A injections. However, general HRQoL was not improved.
format Journal
author Kongsaengdao S.
Maneeton B.
Maneeton N.
spellingShingle Kongsaengdao S.
Maneeton B.
Maneeton N.
Quality of life in cervical dystonia after treatment with botulinum toxin a: A 24-week prospective study
author_facet Kongsaengdao S.
Maneeton B.
Maneeton N.
author_sort Kongsaengdao S.
title Quality of life in cervical dystonia after treatment with botulinum toxin a: A 24-week prospective study
title_short Quality of life in cervical dystonia after treatment with botulinum toxin a: A 24-week prospective study
title_full Quality of life in cervical dystonia after treatment with botulinum toxin a: A 24-week prospective study
title_fullStr Quality of life in cervical dystonia after treatment with botulinum toxin a: A 24-week prospective study
title_full_unstemmed Quality of life in cervical dystonia after treatment with botulinum toxin a: A 24-week prospective study
title_sort quality of life in cervical dystonia after treatment with botulinum toxin a: a 24-week prospective study
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010280708&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/40837
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