Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: A prospective study from Chiang Mai University Hospital, Thailand
Purpose: A report of preliminary results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiation therapy (WP-IMRT) for locally advanced cervical cancer. Material and methods: Fifteen patients with locally advanced cervical cancer were en...
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th-cmuir.6653943832-40842014-08-30T02:35:39Z Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: A prospective study from Chiang Mai University Hospital, Thailand Tharavichitkul E. Wanwilairat S. Chakrabandhu S. Klunklin P. Onchan W. Tippanya D. Nopnop W. Galalae R. Chitapanarux I. Purpose: A report of preliminary results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiation therapy (WP-IMRT) for locally advanced cervical cancer. Material and methods: Fifteen patients with locally advanced cervical cancer were enrolled into the study. WP-IMRT was used to treat the Clinical Target Volume (CTV) with a dose of 45 Gy in 25 fractions. Concurrent cisplatin (40 mg/m2) was prescribed during radiotherapy (RT) on weekly basis. IGBT using computed tomography was performed at the dose of 7 Gy x 4 fractions to the High-Risk Clinical Target Volume (HR-CTV). Results: The mean cumulative doses - in terms of equivalent dose of 2 Gy (EQD2) - of IGBT plus WP-IMRT to HR-CTV, bladder, rectum, and sigmoid colon were 88.3, 85.0, 68.2 and 73.6 Gy, respectively. In comparison with standard (point Aprescription) dose-volume histograms, volume-based image-guided brachytherapy improved the cumulative doses for bladder of 67%, rectum of 47% and sigmoid of 46%. At the median follow-up time of 14 months, the local control, metastasis-free survival and overall survival rates were 93%, 100% and 93%, respectively. No grade 3-4 acute and late toxicities were observed. Conclusion: The combination of image-guided brachytherapy and intensity-modulated radiotherapy improved the dose distribution to tumor volumes and avoided overdose in OARs which could be converted in excellent local control and toxicity profiles. 2014-08-30T02:35:39Z 2014-08-30T02:35:39Z 2013 Article 1689832X 10.5114/jcb.2013.34338 http://www.scopus.com/inward/record.url?eid=2-s2.0-84876837570&partnerID=40&md5=4a3cb045c8f21d6b1d9f8f89662fc479 http://cmuir.cmu.ac.th/handle/6653943832/4084 English |
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Purpose: A report of preliminary results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiation therapy (WP-IMRT) for locally advanced cervical cancer. Material and methods: Fifteen patients with locally advanced cervical cancer were enrolled into the study. WP-IMRT was used to treat the Clinical Target Volume (CTV) with a dose of 45 Gy in 25 fractions. Concurrent cisplatin (40 mg/m2) was prescribed during radiotherapy (RT) on weekly basis. IGBT using computed tomography was performed at the dose of 7 Gy x 4 fractions to the High-Risk Clinical Target Volume (HR-CTV). Results: The mean cumulative doses - in terms of equivalent dose of 2 Gy (EQD2) - of IGBT plus WP-IMRT to HR-CTV, bladder, rectum, and sigmoid colon were 88.3, 85.0, 68.2 and 73.6 Gy, respectively. In comparison with standard (point Aprescription) dose-volume histograms, volume-based image-guided brachytherapy improved the cumulative doses for bladder of 67%, rectum of 47% and sigmoid of 46%. At the median follow-up time of 14 months, the local control, metastasis-free survival and overall survival rates were 93%, 100% and 93%, respectively. No grade 3-4 acute and late toxicities were observed. Conclusion: The combination of image-guided brachytherapy and intensity-modulated radiotherapy improved the dose distribution to tumor volumes and avoided overdose in OARs which could be converted in excellent local control and toxicity profiles. |
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Tharavichitkul E. Wanwilairat S. Chakrabandhu S. Klunklin P. Onchan W. Tippanya D. Nopnop W. Galalae R. Chitapanarux I. |
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Tharavichitkul E. Wanwilairat S. Chakrabandhu S. Klunklin P. Onchan W. Tippanya D. Nopnop W. Galalae R. Chitapanarux I. Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: A prospective study from Chiang Mai University Hospital, Thailand |
author_facet |
Tharavichitkul E. Wanwilairat S. Chakrabandhu S. Klunklin P. Onchan W. Tippanya D. Nopnop W. Galalae R. Chitapanarux I. |
author_sort |
Tharavichitkul E. |
title |
Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: A prospective study from Chiang Mai University Hospital, Thailand |
title_short |
Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: A prospective study from Chiang Mai University Hospital, Thailand |
title_full |
Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: A prospective study from Chiang Mai University Hospital, Thailand |
title_fullStr |
Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: A prospective study from Chiang Mai University Hospital, Thailand |
title_full_unstemmed |
Image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiotherapy (WP-IMRT) for locally advanced cervical cancer: A prospective study from Chiang Mai University Hospital, Thailand |
title_sort |
image-guided brachytherapy (igbt) combined with whole pelvic intensity-modulated radiotherapy (wp-imrt) for locally advanced cervical cancer: a prospective study from chiang mai university hospital, thailand |
publishDate |
2014 |
url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-84876837570&partnerID=40&md5=4a3cb045c8f21d6b1d9f8f89662fc479 http://cmuir.cmu.ac.th/handle/6653943832/4084 |
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1681420170645471232 |