Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity

© 2017 Elsevier B.V. and Mitochondria Research Society. Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ische...

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Main Authors:	Thummasorn S., Shinlapawittayatorn K., Khamseekaew J., Jaiwongkam T., Chattipakorn S., Chattipakorn N.
Format:	Journal
Published:	2017
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027396732&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40862
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-40862
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spelling	th-cmuir.6653943832-408622017-09-28T04:14:14Z Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity Thummasorn S. Shinlapawittayatorn K. Khamseekaew J. Jaiwongkam T. Chattipakorn S. Chattipakorn N. © 2017 Elsevier B.V. and Mitochondria Research Society. Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischemia/reperfusion (I/R) injury via attenuating mitochondrial dysfunction. However, it is unclear if HNG has direct effects on mitochondrial function against oxidative stress. Thus, we sought to determine the effects of HNG on mitochondrial function under hydrogen peroxide (H 2 O 2 ) induced oxidative stress in isolated cardiac mitochondria. We found that HNG has direct protective effects on cardiac mitochondrial function against H 2 O 2 induced oxidative stress through decreasing complex I activity. 2017-09-28T04:14:14Z 2017-09-28T04:14:14Z 2017-01-01 Journal 15677249 2-s2.0-85027396732 10.1016/j.mito.2017.08.001 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027396732&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40862
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
description	© 2017 Elsevier B.V. and Mitochondria Research Society. Humanin (HN) is an endogenous peptide that exerts cytoprotection against oxidative stress and apoptosis. We recently reported that Humanin analogue (HNG) pretreatment can reduce reactive oxygen species production in the heart subjected to ischemia/reperfusion (I/R) injury via attenuating mitochondrial dysfunction. However, it is unclear if HNG has direct effects on mitochondrial function against oxidative stress. Thus, we sought to determine the effects of HNG on mitochondrial function under hydrogen peroxide (H 2 O 2 ) induced oxidative stress in isolated cardiac mitochondria. We found that HNG has direct protective effects on cardiac mitochondrial function against H 2 O 2 induced oxidative stress through decreasing complex I activity.
format	Journal
author	Thummasorn S. Shinlapawittayatorn K. Khamseekaew J. Jaiwongkam T. Chattipakorn S. Chattipakorn N.
spellingShingle	Thummasorn S. Shinlapawittayatorn K. Khamseekaew J. Jaiwongkam T. Chattipakorn S. Chattipakorn N. Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
author_facet	Thummasorn S. Shinlapawittayatorn K. Khamseekaew J. Jaiwongkam T. Chattipakorn S. Chattipakorn N.
author_sort	Thummasorn S.
title	Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_short	Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_full	Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_fullStr	Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_full_unstemmed	Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity
title_sort	humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex i activity
publishDate	2017
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027396732&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40862
_version_	1681421895848689664

Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity

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