Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities

Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities

© 2017, Chiang Mai University. All rights reserved. Three new polycyclic containing sulfur compounds, Combretanoid, Combretanane and Combretanun, were isolated. The crude ethanolic extract and pure compound Combretin, the isolated pure compound from the seeds of Combretum quadrangulare Kurz (Combret...

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Main Authors: Nantachit K., Sirilun S., Nobsathian S., Rungjang S.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010791380&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/40991
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spelling th-cmuir.6653943832-409912017-09-28T04:14:56Z Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities Nantachit K. Sirilun S. Nobsathian S. Rungjang S. © 2017, Chiang Mai University. All rights reserved. Three new polycyclic containing sulfur compounds, Combretanoid, Combretanane and Combretanun, were isolated. The crude ethanolic extract and pure compound Combretin, the isolated pure compound from the seeds of Combretum quadrangulare Kurz (Combretaceae), showed antimicrobial activities against many pathogens. The aim of this study was to determine antifungal activity against opportunistic pathogens in HIV patients and anti-mycobacterium tuberculosis activity (anti-TB). An Antifungal test was performed by agar dilution method and an anti-TB test was done using green fluorescent protein microplate assay (GFPMA). Crude ethanolic extract from Amphur Sun Srai showed antifungal activity against A. fumigatus better than the extract from Amphur Sarapee. Combretanoid showed no antifungal activity and the three new compounds showed no anti-TB activity. This plant showed no toxicity to albino rat and mice. In conclusion, it may used as a traditional method for antifungal activity against A. fumigatus. 2017-09-28T04:14:56Z 2017-09-28T04:14:56Z 2017-01-01 Journal 01252526 2-s2.0-85010791380 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010791380&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40991
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2017, Chiang Mai University. All rights reserved. Three new polycyclic containing sulfur compounds, Combretanoid, Combretanane and Combretanun, were isolated. The crude ethanolic extract and pure compound Combretin, the isolated pure compound from the seeds of Combretum quadrangulare Kurz (Combretaceae), showed antimicrobial activities against many pathogens. The aim of this study was to determine antifungal activity against opportunistic pathogens in HIV patients and anti-mycobacterium tuberculosis activity (anti-TB). An Antifungal test was performed by agar dilution method and an anti-TB test was done using green fluorescent protein microplate assay (GFPMA). Crude ethanolic extract from Amphur Sun Srai showed antifungal activity against A. fumigatus better than the extract from Amphur Sarapee. Combretanoid showed no antifungal activity and the three new compounds showed no anti-TB activity. This plant showed no toxicity to albino rat and mice. In conclusion, it may used as a traditional method for antifungal activity against A. fumigatus.
format Journal
author Nantachit K.
Sirilun S.
Nobsathian S.
Rungjang S.
spellingShingle Nantachit K.
Sirilun S.
Nobsathian S.
Rungjang S.
Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities
author_facet Nantachit K.
Sirilun S.
Nobsathian S.
Rungjang S.
author_sort Nantachit K.
title Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities
title_short Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities
title_full Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities
title_fullStr Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities
title_full_unstemmed Three new polycyclic containing sulfur compounds from the seeds of Combretum quadrangulare kurz (Combretaceae), antifungal and anti-mycobacterium activities
title_sort three new polycyclic containing sulfur compounds from the seeds of combretum quadrangulare kurz (combretaceae), antifungal and anti-mycobacterium activities
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010791380&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/40991
_version_ 1681421919486738432

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