Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa

The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made wi...

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Main Authors: Polbuppha I., Maneerat W., Sripisut T., Limtharakul T., Cheenpracha S., Pyne S., Muanprasat C., Seemakhan S., Borwornpinyo S., Laphookhieo S.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026481448&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41149
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-411492017-09-28T04:15:50Z Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa Polbuppha I. Maneerat W. Sripisut T. Limtharakul T. Cheenpracha S. Pyne S. Muanprasat C. Seemakhan S. Borwornpinyo S. Laphookhieo S. The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC 50 values ranging from 7.45-V16.12 μM. Compound 4 also exhibited potent activity against ABTS.,h + scavenging activity with an IC 50 value of 0.55 iÓ 0.01 £gM which was better than positive control (ascorbic acid, IC 50 2.35-0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC 50 value of 0.02-0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC 50 values ranging from 22.35-47.62 μM. 2017-09-28T04:15:50Z 2017-09-28T04:15:50Z 2017-01-01 Journal 1934578X 2-s2.0-85026481448 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026481448&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41149
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC 50 values ranging from 7.45-V16.12 μM. Compound 4 also exhibited potent activity against ABTS.,h + scavenging activity with an IC 50 value of 0.55 iÓ 0.01 £gM which was better than positive control (ascorbic acid, IC 50 2.35-0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC 50 value of 0.02-0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC 50 values ranging from 22.35-47.62 μM.
format Journal
author Polbuppha I.
Maneerat W.
Sripisut T.
Limtharakul T.
Cheenpracha S.
Pyne S.
Muanprasat C.
Seemakhan S.
Borwornpinyo S.
Laphookhieo S.
spellingShingle Polbuppha I.
Maneerat W.
Sripisut T.
Limtharakul T.
Cheenpracha S.
Pyne S.
Muanprasat C.
Seemakhan S.
Borwornpinyo S.
Laphookhieo S.
Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
author_facet Polbuppha I.
Maneerat W.
Sripisut T.
Limtharakul T.
Cheenpracha S.
Pyne S.
Muanprasat C.
Seemakhan S.
Borwornpinyo S.
Laphookhieo S.
author_sort Polbuppha I.
title Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
title_short Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
title_full Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
title_fullStr Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
title_full_unstemmed Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
title_sort antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026481448&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41149
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