Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This study focused on the chemopreventive effects of Spirogyra neglecta extract (SNE) and dried S. neglecta mixed diet on the early stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats. Male Wistar rats were inje...
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th-cmuir.6653943832-412092017-09-28T04:20:00Z Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats Taya S. Thumvijit T. Chewonarin T. Punvittayagul C. Wongpoomchai R. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This study focused on the chemopreventive effects of Spirogyra neglecta extract (SNE) and dried S. neglecta mixed diet on the early stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats. Male Wistar rats were injected with DMH to initiate aberrant crypt foci (ACF) formation. In the initiation stage, SNE significantly decreased the number of ACF in the colon of DMH-treated rats. Rats that received a low dose of SNE showed enhanced activity of several detoxifying and antioxidant enzymes. In the postinitiation stage, a low dose of SNE significantly decreased the number of ACF in the colon of DMH-treated rats. It significantly reduced the number of proliferating cell nuclear antigen-positive cells and increased the number of apoptotic cells in colonic crypts. S. neglecta thus inhibited the development of the early stages of DMH-induced colon carcinogenesis in rats by modulation of xenobiotic metabolizing enzymes and inhibition of cell proliferation as well as induction of apoptosis. 2017-09-28T04:20:00Z 2017-09-28T04:20:00Z 2016-12-06 Journal 09598278 2-s2.0-85002180312 10.1097/CEJ.0000000000000320 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85002180312&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41209 |
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Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This study focused on the chemopreventive effects of Spirogyra neglecta extract (SNE) and dried S. neglecta mixed diet on the early stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats. Male Wistar rats were injected with DMH to initiate aberrant crypt foci (ACF) formation. In the initiation stage, SNE significantly decreased the number of ACF in the colon of DMH-treated rats. Rats that received a low dose of SNE showed enhanced activity of several detoxifying and antioxidant enzymes. In the postinitiation stage, a low dose of SNE significantly decreased the number of ACF in the colon of DMH-treated rats. It significantly reduced the number of proliferating cell nuclear antigen-positive cells and increased the number of apoptotic cells in colonic crypts. S. neglecta thus inhibited the development of the early stages of DMH-induced colon carcinogenesis in rats by modulation of xenobiotic metabolizing enzymes and inhibition of cell proliferation as well as induction of apoptosis. |
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author |
Taya S. Thumvijit T. Chewonarin T. Punvittayagul C. Wongpoomchai R. |
spellingShingle |
Taya S. Thumvijit T. Chewonarin T. Punvittayagul C. Wongpoomchai R. Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats |
author_facet |
Taya S. Thumvijit T. Chewonarin T. Punvittayagul C. Wongpoomchai R. |
author_sort |
Taya S. |
title |
Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats |
title_short |
Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats |
title_full |
Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats |
title_fullStr |
Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats |
title_full_unstemmed |
Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats |
title_sort |
effect of spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats |
publishDate |
2017 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85002180312&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41209 |
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