The correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies

© Wangkaew et al.; Licensee Bentham Open. Objectives: To compare the muscle pathology findings among subgroups of idiopathic inflammatory myopathies (IIM) patients, and to determine the correlations of muscle biopsy scores with muscle power and creatine kinase (CK). Methods: The medical records of I...

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Main Authors: Wangkaew S., Suwansirikul S., Aroonrungwichian K., Kasitanon N., Louthrenoo W.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008367660&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41239
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spelling th-cmuir.6653943832-412392017-09-28T04:20:07Z The correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies Wangkaew S. Suwansirikul S. Aroonrungwichian K. Kasitanon N. Louthrenoo W. © Wangkaew et al.; Licensee Bentham Open. Objectives: To compare the muscle pathology findings among subgroups of idiopathic inflammatory myopathies (IIM) patients, and to determine the correlations of muscle biopsy scores with muscle power and creatine kinase (CK). Methods: The medical records of IIM patients consisting of the demographic data, clinical parameters and laboratory conducted were retrospectively reviewed. Their initial muscle biopsies were reviewed, and four domains were scored: inflammation, vascular, muscle, and connective tissue. Results: Ninety-five IIM patients (28 patients with idiopathic polymyositis (PM) 9 idiopathic dermatomyositis (DM), 5 DM associated with malignancy, and 53 PM/DM associated with connective tissue disease) with median (IQR: Q1, Q3) disease duration of 1.2 (0.5, 3.1) months were included. No significant differences in initial muscle pathology findings and muscle pathology score among the subgroups were found. Muscle degeneration and endomysial fibrosis scores were negatively correlated with muscle power (r=-0.23 and-0.24, respectively, p < 0.05) and positively correlated with CK (r=0.27 and 0.39, respectively, p < 0.01). No significant correlation was detected either inflammation or vasculitis scores with muscle power and CK levels. Conclusion: In this study, muscle biopsy cannot be used to differentiate among subgroups of IIM patients. In addition, we found only modest correlation of muscle biopsy scores with muscle power and CK. Further study is necessary to confirm our findings. 2017-09-28T04:20:07Z 2017-09-28T04:20:07Z 2016-12-01 Journal 2-s2.0-85008367660 10.2174/1874312901610010141 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008367660&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41239
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
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description © Wangkaew et al.; Licensee Bentham Open. Objectives: To compare the muscle pathology findings among subgroups of idiopathic inflammatory myopathies (IIM) patients, and to determine the correlations of muscle biopsy scores with muscle power and creatine kinase (CK). Methods: The medical records of IIM patients consisting of the demographic data, clinical parameters and laboratory conducted were retrospectively reviewed. Their initial muscle biopsies were reviewed, and four domains were scored: inflammation, vascular, muscle, and connective tissue. Results: Ninety-five IIM patients (28 patients with idiopathic polymyositis (PM) 9 idiopathic dermatomyositis (DM), 5 DM associated with malignancy, and 53 PM/DM associated with connective tissue disease) with median (IQR: Q1, Q3) disease duration of 1.2 (0.5, 3.1) months were included. No significant differences in initial muscle pathology findings and muscle pathology score among the subgroups were found. Muscle degeneration and endomysial fibrosis scores were negatively correlated with muscle power (r=-0.23 and-0.24, respectively, p < 0.05) and positively correlated with CK (r=0.27 and 0.39, respectively, p < 0.01). No significant correlation was detected either inflammation or vasculitis scores with muscle power and CK levels. Conclusion: In this study, muscle biopsy cannot be used to differentiate among subgroups of IIM patients. In addition, we found only modest correlation of muscle biopsy scores with muscle power and CK. Further study is necessary to confirm our findings.
format Journal
author Wangkaew S.
Suwansirikul S.
Aroonrungwichian K.
Kasitanon N.
Louthrenoo W.
spellingShingle Wangkaew S.
Suwansirikul S.
Aroonrungwichian K.
Kasitanon N.
Louthrenoo W.
The correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies
author_facet Wangkaew S.
Suwansirikul S.
Aroonrungwichian K.
Kasitanon N.
Louthrenoo W.
author_sort Wangkaew S.
title The correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies
title_short The correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies
title_full The correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies
title_fullStr The correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies
title_full_unstemmed The correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies
title_sort correlation of muscle biopsy scores with the clinical variables in idiopathic inflammatory myopathies
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008367660&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41239
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