Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults

Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults

© 2016 Wolters Kluwer Health, Inc. All rights reserved. HIV protease inhibitor use in pediatrics is challenging due to the poor palatability and/or toxicity of concomitant low-dose ritonavir. Atazanavir without ritonavir (unboosted) is not recommended for patients with prior virologic failure, a com...

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Main Authors: Cressey T., Hazra R., Wiznia A., Foca M., Jean-Philippe P., Graham B., King J., Britto P., Carey V., Acosta E., Yogev R.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84984700603&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41295
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Institution: Chiang Mai University
id th-cmuir.6653943832-41295
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spelling th-cmuir.6653943832-412952017-09-28T04:20:27Z Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults Cressey T. Hazra R. Wiznia A. Foca M. Jean-Philippe P. Graham B. King J. Britto P. Carey V. Acosta E. Yogev R. © 2016 Wolters Kluwer Health, Inc. All rights reserved. HIV protease inhibitor use in pediatrics is challenging due to the poor palatability and/or toxicity of concomitant low-dose ritonavir. Atazanavir without ritonavir (unboosted) is not recommended for patients with prior virologic failure, a common problem for perinatally-infected adolescents. Atazanavir 400 mg once-daily provided suboptimal exposure. Higher unboosted doses or splitting the daily dose to twice-daily warrants investigation in this treatment-experienced population. 2017-09-28T04:20:27Z 2017-09-28T04:20:27Z 2016-11-28 Journal 08913668 2-s2.0-84984700603 10.1097/INF.0000000000001320 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84984700603&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41295
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2016 Wolters Kluwer Health, Inc. All rights reserved. HIV protease inhibitor use in pediatrics is challenging due to the poor palatability and/or toxicity of concomitant low-dose ritonavir. Atazanavir without ritonavir (unboosted) is not recommended for patients with prior virologic failure, a common problem for perinatally-infected adolescents. Atazanavir 400 mg once-daily provided suboptimal exposure. Higher unboosted doses or splitting the daily dose to twice-daily warrants investigation in this treatment-experienced population.
format Journal
author Cressey T.
Hazra R.
Wiznia A.
Foca M.
Jean-Philippe P.
Graham B.
King J.
Britto P.
Carey V.
Acosta E.
Yogev R.
spellingShingle Cressey T.
Hazra R.
Wiznia A.
Foca M.
Jean-Philippe P.
Graham B.
King J.
Britto P.
Carey V.
Acosta E.
Yogev R.
Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults
author_facet Cressey T.
Hazra R.
Wiznia A.
Foca M.
Jean-Philippe P.
Graham B.
King J.
Britto P.
Carey V.
Acosta E.
Yogev R.
author_sort Cressey T.
title Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults
title_short Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults
title_full Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults
title_fullStr Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults
title_full_unstemmed Pharmacokinetics of unboosted atazanavir in treatment-experienced HIV-infected children, adolescents and young adults
title_sort pharmacokinetics of unboosted atazanavir in treatment-experienced hiv-infected children, adolescents and young adults
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84984700603&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41295
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