Effect of surface modification of poly(L-lactide-co-ε-caprolactone) membranes by low-pressure plasma on support cell biocompatibility
© 2016 Elsevier B.V. There has been a lack of success in using synthetic nerve guides to close long lesion gaps. However, new approaches in molecular design, synthesis and fabrication offer great promise. In this study, a 13.56 MHz inductively-coupled discharge plasma reactor with an ammonia and arg...
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| Main Authors: | , , , , , , , , , |
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| Format: | Journal |
| Published: |
2017
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| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84994048471&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41317 |
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| Institution: | Chiang Mai University |
| Summary: | © 2016 Elsevier B.V. There has been a lack of success in using synthetic nerve guides to close long lesion gaps. However, new approaches in molecular design, synthesis and fabrication offer great promise. In this study, a 13.56 MHz inductively-coupled discharge plasma reactor with an ammonia and argon gas mix was used to modify the surfaces of synthetic, biodegradable copolyester poly(L-lactide-co-ε-caprolactone) (PLCL, 70:30 mol%) electrospun membranes. The presence of [sbnd]NH 2 groups on the PLCL surface were revealed by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). Vibrational calculation of NH 3 adsorbed on the membrane surface of PLCL was determined through DFT calculations. Membranes of PLCL treated with NH 3 showed significantly greater hydrophilicities which were a consequence of the NH 3 plasma-induced polar groups. Treated membranes had reduced cell adhesion barriers and consequently greater cell adhesion suggesting enhanced biocompatibilities compared to their untreated counterparts. Thus, PLCL membranes treated with NH 3 plasma have been shown to be promising materials for use as absorbable nerve guides. |
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