The effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: A prospective, randomized, double-blind, and placebo-controlled trial

The purpose of this study was to determine the effect of dexmedetomidine on hemodynamic responses to DLT intubation compared to placebo and to assess the adverse effects related to dexmedetomidine. Sixty patients were randomly allocated to receive 0.7 g/kg dexmedetomidine (n=30) or normal saline (n=...

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Main Authors: Pipanmekaporn T., Punjasawadwong Y., Charuluxananan S., Lapisatepun W., Bunburaphong P.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84883198846&partnerID=40&md5=404c5230b59cfda6f62593a1334ff275
http://www.ncbi.nlm.nih.gov/pubmed/23983684
http://cmuir.cmu.ac.th/handle/6653943832/4132
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-41322014-08-30T02:35:42Z The effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: A prospective, randomized, double-blind, and placebo-controlled trial Pipanmekaporn T. Punjasawadwong Y. Charuluxananan S. Lapisatepun W. Bunburaphong P. The purpose of this study was to determine the effect of dexmedetomidine on hemodynamic responses to DLT intubation compared to placebo and to assess the adverse effects related to dexmedetomidine. Sixty patients were randomly allocated to receive 0.7 g/kg dexmedetomidine (n=30) or normal saline (n=30) 10 minutes before general anesthesia. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and rate pressure product (RPP) between groups were recorded. During intubation and 10 minutes afterward (T1-T10), the mean SBP, DBP, MAP, HR, and RPP in the control group were significantly higher than those in the dexmedetomidine group throughout the study period except at T1. The mean differences of SBP, DBP, MAP, HR, and RPP were significantly higher in the control group, with the value of 15.2 mmHg, 10.5 mmHg, 14 mmHg, 10.5 beats per minute, and 2,462.8 mmHg min -1. Four patients in the dexmedetomidine group and 1 patient in the control group developed hypotension, while 2 patients in the dexmedetomidine group had bradycardia. Prophylactic dexmedetomidine can attenuate the hemodynamic responses to laryngoscopy and DLT intubation with minimal adverse effects. This trial is registered with ClinicalTrials.gov NCT01289769. © 2013 Tanyong Pipanmekaporn et al. 2014-08-30T02:35:42Z 2014-08-30T02:35:42Z 2013 Article 16876962 10.1155/2013/236089 http://www.scopus.com/inward/record.url?eid=2-s2.0-84883198846&partnerID=40&md5=404c5230b59cfda6f62593a1334ff275 http://www.ncbi.nlm.nih.gov/pubmed/23983684 http://cmuir.cmu.ac.th/handle/6653943832/4132 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The purpose of this study was to determine the effect of dexmedetomidine on hemodynamic responses to DLT intubation compared to placebo and to assess the adverse effects related to dexmedetomidine. Sixty patients were randomly allocated to receive 0.7 g/kg dexmedetomidine (n=30) or normal saline (n=30) 10 minutes before general anesthesia. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and rate pressure product (RPP) between groups were recorded. During intubation and 10 minutes afterward (T1-T10), the mean SBP, DBP, MAP, HR, and RPP in the control group were significantly higher than those in the dexmedetomidine group throughout the study period except at T1. The mean differences of SBP, DBP, MAP, HR, and RPP were significantly higher in the control group, with the value of 15.2 mmHg, 10.5 mmHg, 14 mmHg, 10.5 beats per minute, and 2,462.8 mmHg min -1. Four patients in the dexmedetomidine group and 1 patient in the control group developed hypotension, while 2 patients in the dexmedetomidine group had bradycardia. Prophylactic dexmedetomidine can attenuate the hemodynamic responses to laryngoscopy and DLT intubation with minimal adverse effects. This trial is registered with ClinicalTrials.gov NCT01289769. © 2013 Tanyong Pipanmekaporn et al.
format Article
author Pipanmekaporn T.
Punjasawadwong Y.
Charuluxananan S.
Lapisatepun W.
Bunburaphong P.
spellingShingle Pipanmekaporn T.
Punjasawadwong Y.
Charuluxananan S.
Lapisatepun W.
Bunburaphong P.
The effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: A prospective, randomized, double-blind, and placebo-controlled trial
author_facet Pipanmekaporn T.
Punjasawadwong Y.
Charuluxananan S.
Lapisatepun W.
Bunburaphong P.
author_sort Pipanmekaporn T.
title The effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: A prospective, randomized, double-blind, and placebo-controlled trial
title_short The effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: A prospective, randomized, double-blind, and placebo-controlled trial
title_full The effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: A prospective, randomized, double-blind, and placebo-controlled trial
title_fullStr The effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: A prospective, randomized, double-blind, and placebo-controlled trial
title_full_unstemmed The effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: A prospective, randomized, double-blind, and placebo-controlled trial
title_sort effect of prophylactic dexmedetomidine on hemodynamic disturbances to double-lumen endotracheal intubation: a prospective, randomized, double-blind, and placebo-controlled trial
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84883198846&partnerID=40&md5=404c5230b59cfda6f62593a1334ff275
http://www.ncbi.nlm.nih.gov/pubmed/23983684
http://cmuir.cmu.ac.th/handle/6653943832/4132
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