The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock
© 2016 Katip et al. Objective: To characterize the pharmacokinetics (PK) of vancomycin in patients in the initial phase of septic shock. Methods: Twelve patients with septic shock received an intravenous infusion of vancomycin 30 mg/kg over 2 h. The vancomycin PK study was conducted during the first...
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th-cmuir.6653943832-413332017-09-28T04:20:41Z The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock Katip W. Jaruratanasirikul S. Pattharachayakul S. Wongpoowarak W. Jitsurong A. Lucksiri A. © 2016 Katip et al. Objective: To characterize the pharmacokinetics (PK) of vancomycin in patients in the initial phase of septic shock. Methods: Twelve patients with septic shock received an intravenous infusion of vancomycin 30 mg/kg over 2 h. The vancomycin PK study was conducted during the first 12 h of the regimen. Serum vancomycin concentration-time data were analyzed using the standard model-independent analysis and the compartment model. Results: For the noncompartment analysis the mean values ± standard deviation (SD) of the estimated clearance and volume of distribution of vancomycin at steady state were 6.05±1.06 L/h and 78.73±21.78 L, respectively. For the compartmental analysis, the majority of vancomycin concentration-time profiles were best described by a two-compartment PK model. Thus, the two-compartmental first-order elimination model was used for the analysis. The mean ± SD of the total clearance (3.70±1.25 L/h) of vancomycin was higher than that obtained from patients without septic shock. In contrast, the volume of the central compartment (8.34±4.36 L) and volume of peripheral compartment (30.99±7.84 L) did not increase when compared with patients without septic shock. Conclusion: The total clearance of vancomycin was increased in septic shock patients. However, the volume of the central compartment and peripheral compartment did not increase. Consequently, a loading dose of vancomycin should be considered in all patients with septic shock. 2017-09-28T04:20:41Z 2017-09-28T04:20:41Z 2016-11-22 Journal 2-s2.0-85003634416 10.2147/IDR.S121513 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85003634416&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41333 |
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© 2016 Katip et al. Objective: To characterize the pharmacokinetics (PK) of vancomycin in patients in the initial phase of septic shock. Methods: Twelve patients with septic shock received an intravenous infusion of vancomycin 30 mg/kg over 2 h. The vancomycin PK study was conducted during the first 12 h of the regimen. Serum vancomycin concentration-time data were analyzed using the standard model-independent analysis and the compartment model. Results: For the noncompartment analysis the mean values ± standard deviation (SD) of the estimated clearance and volume of distribution of vancomycin at steady state were 6.05±1.06 L/h and 78.73±21.78 L, respectively. For the compartmental analysis, the majority of vancomycin concentration-time profiles were best described by a two-compartment PK model. Thus, the two-compartmental first-order elimination model was used for the analysis. The mean ± SD of the total clearance (3.70±1.25 L/h) of vancomycin was higher than that obtained from patients without septic shock. In contrast, the volume of the central compartment (8.34±4.36 L) and volume of peripheral compartment (30.99±7.84 L) did not increase when compared with patients without septic shock. Conclusion: The total clearance of vancomycin was increased in septic shock patients. However, the volume of the central compartment and peripheral compartment did not increase. Consequently, a loading dose of vancomycin should be considered in all patients with septic shock. |
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Katip W. Jaruratanasirikul S. Pattharachayakul S. Wongpoowarak W. Jitsurong A. Lucksiri A. |
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Katip W. Jaruratanasirikul S. Pattharachayakul S. Wongpoowarak W. Jitsurong A. Lucksiri A. The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock |
author_facet |
Katip W. Jaruratanasirikul S. Pattharachayakul S. Wongpoowarak W. Jitsurong A. Lucksiri A. |
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Katip W. |
title |
The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock |
title_short |
The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock |
title_full |
The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock |
title_fullStr |
The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock |
title_full_unstemmed |
The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock |
title_sort |
pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock |
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2017 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85003634416&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41333 |
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