The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock

© 2016 Katip et al. Objective: To characterize the pharmacokinetics (PK) of vancomycin in patients in the initial phase of septic shock. Methods: Twelve patients with septic shock received an intravenous infusion of vancomycin 30 mg/kg over 2 h. The vancomycin PK study was conducted during the first...

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Main Authors: Katip W., Jaruratanasirikul S., Pattharachayakul S., Wongpoowarak W., Jitsurong A., Lucksiri A.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85003634416&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41333
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spelling th-cmuir.6653943832-413332017-09-28T04:20:41Z The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock Katip W. Jaruratanasirikul S. Pattharachayakul S. Wongpoowarak W. Jitsurong A. Lucksiri A. © 2016 Katip et al. Objective: To characterize the pharmacokinetics (PK) of vancomycin in patients in the initial phase of septic shock. Methods: Twelve patients with septic shock received an intravenous infusion of vancomycin 30 mg/kg over 2 h. The vancomycin PK study was conducted during the first 12 h of the regimen. Serum vancomycin concentration-time data were analyzed using the standard model-independent analysis and the compartment model. Results: For the noncompartment analysis the mean values ± standard deviation (SD) of the estimated clearance and volume of distribution of vancomycin at steady state were 6.05±1.06 L/h and 78.73±21.78 L, respectively. For the compartmental analysis, the majority of vancomycin concentration-time profiles were best described by a two-compartment PK model. Thus, the two-compartmental first-order elimination model was used for the analysis. The mean ± SD of the total clearance (3.70±1.25 L/h) of vancomycin was higher than that obtained from patients without septic shock. In contrast, the volume of the central compartment (8.34±4.36 L) and volume of peripheral compartment (30.99±7.84 L) did not increase when compared with patients without septic shock. Conclusion: The total clearance of vancomycin was increased in septic shock patients. However, the volume of the central compartment and peripheral compartment did not increase. Consequently, a loading dose of vancomycin should be considered in all patients with septic shock. 2017-09-28T04:20:41Z 2017-09-28T04:20:41Z 2016-11-22 Journal 2-s2.0-85003634416 10.2147/IDR.S121513 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85003634416&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41333
institution Chiang Mai University
building Chiang Mai University Library
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description © 2016 Katip et al. Objective: To characterize the pharmacokinetics (PK) of vancomycin in patients in the initial phase of septic shock. Methods: Twelve patients with septic shock received an intravenous infusion of vancomycin 30 mg/kg over 2 h. The vancomycin PK study was conducted during the first 12 h of the regimen. Serum vancomycin concentration-time data were analyzed using the standard model-independent analysis and the compartment model. Results: For the noncompartment analysis the mean values ± standard deviation (SD) of the estimated clearance and volume of distribution of vancomycin at steady state were 6.05±1.06 L/h and 78.73±21.78 L, respectively. For the compartmental analysis, the majority of vancomycin concentration-time profiles were best described by a two-compartment PK model. Thus, the two-compartmental first-order elimination model was used for the analysis. The mean ± SD of the total clearance (3.70±1.25 L/h) of vancomycin was higher than that obtained from patients without septic shock. In contrast, the volume of the central compartment (8.34±4.36 L) and volume of peripheral compartment (30.99±7.84 L) did not increase when compared with patients without septic shock. Conclusion: The total clearance of vancomycin was increased in septic shock patients. However, the volume of the central compartment and peripheral compartment did not increase. Consequently, a loading dose of vancomycin should be considered in all patients with septic shock.
format Journal
author Katip W.
Jaruratanasirikul S.
Pattharachayakul S.
Wongpoowarak W.
Jitsurong A.
Lucksiri A.
spellingShingle Katip W.
Jaruratanasirikul S.
Pattharachayakul S.
Wongpoowarak W.
Jitsurong A.
Lucksiri A.
The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock
author_facet Katip W.
Jaruratanasirikul S.
Pattharachayakul S.
Wongpoowarak W.
Jitsurong A.
Lucksiri A.
author_sort Katip W.
title The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock
title_short The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock
title_full The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock
title_fullStr The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock
title_full_unstemmed The pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock
title_sort pharmacokinetics of vancomycin during the initial loading dose in patients with septic shock
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85003634416&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41333
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