Looking for Ocular Tuberculosis: Prevalence and Clinical Manifestations of Patients with Uveitis and Positive QuantiFERON<sup>®</sup>-TB Gold Test
© 2016, Taylor & Francis. All rights reserved. Purpose: To report on the prevalence of ocular TB and positive QuantiFERON ® -TB Gold (QFT-G) test in uveitis patients and describe their clinical manifestations. Methods: We performed a prospective study of 108 new human immunodeficiency virus-ne...
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th-cmuir.6653943832-413362017-09-28T04:20:41Z Looking for Ocular Tuberculosis: Prevalence and Clinical Manifestations of Patients with Uveitis and Positive QuantiFERON<sup>®</sup>-TB Gold Test Pathanapitoon K. Kunavisarut P. Sirirungsi W. Rothova A. © 2016, Taylor & Francis. All rights reserved. Purpose: To report on the prevalence of ocular TB and positive QuantiFERON ® -TB Gold (QFT-G) test in uveitis patients and describe their clinical manifestations. Methods: We performed a prospective study of 108 new human immunodeficiency virus-negative uveitis patients. All patients underwent a tailored screening protocol for uveitis and received QFT-G test and tuberculin skin tests (TST). Results: QFT-G test was positive in 39/108 (36%) of patients, while TST ≥15 mm was positive in 16/108 (15%) patients. None of the patients were identified with active systemic TB. Out of 39 QFT-G-positive patients, 25 (64%) were of unknown cause, which represents a higher proportion than encountered in QFT-G-negative cases (29/69; 42%; p < 0.03). Retinal occlusive vasculitis was frequently observed in patients with positive QFT-G outcomes (10/39 vs 3/69; p = 0.001) and was commonly associated with high QFT-G levels, young age, and male gender. Conclusions: Out of all patients with uveitis, none had active systemic TB but 36% were positive for QFT-G test. QFT-G-positive patients frequently had uveitis of unknown cause and exhibited clinical features of occlusive retinal vasculitis. 2017-09-28T04:20:41Z 2017-09-28T04:20:41Z 2016-11-18 Journal 09273948 2-s2.0-84995519397 10.1080/09273948.2016.1245760 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995519397&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41336 |
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© 2016, Taylor & Francis. All rights reserved. Purpose: To report on the prevalence of ocular TB and positive QuantiFERON ® -TB Gold (QFT-G) test in uveitis patients and describe their clinical manifestations. Methods: We performed a prospective study of 108 new human immunodeficiency virus-negative uveitis patients. All patients underwent a tailored screening protocol for uveitis and received QFT-G test and tuberculin skin tests (TST). Results: QFT-G test was positive in 39/108 (36%) of patients, while TST ≥15 mm was positive in 16/108 (15%) patients. None of the patients were identified with active systemic TB. Out of 39 QFT-G-positive patients, 25 (64%) were of unknown cause, which represents a higher proportion than encountered in QFT-G-negative cases (29/69; 42%; p < 0.03). Retinal occlusive vasculitis was frequently observed in patients with positive QFT-G outcomes (10/39 vs 3/69; p = 0.001) and was commonly associated with high QFT-G levels, young age, and male gender. Conclusions: Out of all patients with uveitis, none had active systemic TB but 36% were positive for QFT-G test. QFT-G-positive patients frequently had uveitis of unknown cause and exhibited clinical features of occlusive retinal vasculitis. |
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Pathanapitoon K. Kunavisarut P. Sirirungsi W. Rothova A. |
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Pathanapitoon K. Kunavisarut P. Sirirungsi W. Rothova A. Looking for Ocular Tuberculosis: Prevalence and Clinical Manifestations of Patients with Uveitis and Positive QuantiFERON<sup>®</sup>-TB Gold Test |
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Pathanapitoon K. Kunavisarut P. Sirirungsi W. Rothova A. |
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Pathanapitoon K. |
title |
Looking for Ocular Tuberculosis: Prevalence and Clinical Manifestations of Patients with Uveitis and Positive QuantiFERON<sup>®</sup>-TB Gold Test |
title_short |
Looking for Ocular Tuberculosis: Prevalence and Clinical Manifestations of Patients with Uveitis and Positive QuantiFERON<sup>®</sup>-TB Gold Test |
title_full |
Looking for Ocular Tuberculosis: Prevalence and Clinical Manifestations of Patients with Uveitis and Positive QuantiFERON<sup>®</sup>-TB Gold Test |
title_fullStr |
Looking for Ocular Tuberculosis: Prevalence and Clinical Manifestations of Patients with Uveitis and Positive QuantiFERON<sup>®</sup>-TB Gold Test |
title_full_unstemmed |
Looking for Ocular Tuberculosis: Prevalence and Clinical Manifestations of Patients with Uveitis and Positive QuantiFERON<sup>®</sup>-TB Gold Test |
title_sort |
looking for ocular tuberculosis: prevalence and clinical manifestations of patients with uveitis and positive quantiferon<sup>®</sup>-tb gold test |
publishDate |
2017 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995519397&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41336 |
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