Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling

• Main Authors: Chanmee T., Ontong P., Izumikawa T., Higashide M., Mochizuki N., Chokchaitaweesuk C., Khansai M., Nakajima K., Kakizaki I., Kongtawelert P., Taniguchi N., Itano N.
• Format: Journal
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995450861&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/41349
• Institution: Chiang Mai University

Cancer stem cells (CSCs) represent a small subpopulation of self-renewing oncogenic cells. As in many other stem cells, metabolic reprogramming has been implicated to be a key characteristic of CSCs. However, little is known about how the metabolic features of cancer cells are controlled to orchestr...