Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol

Objective: To assess the efficacy and maternal side-effects of oral misoprostol for second trimester termination of pregnancies with intrauterine fetal death. Methods: A prospective descriptive study was conducted on 63 pregnant women who had intrauterine fetal death with unfavorable cervix (Bishop...

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Main Authors: Pongsatha S., Tongsong T.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-3042831727&partnerID=40&md5=f2fa279ceffb40515db5cbfc27bb2780
http://www.ncbi.nlm.nih.gov/pubmed/15210046
http://cmuir.cmu.ac.th/handle/6653943832/4140
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-41402014-08-30T02:35:43Z Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol Pongsatha S. Tongsong T. Objective: To assess the efficacy and maternal side-effects of oral misoprostol for second trimester termination of pregnancies with intrauterine fetal death. Methods: A prospective descriptive study was conducted on 63 pregnant women who had intrauterine fetal death with unfavorable cervix (Bishop scores ≤4). All received 400 μg of misoprostol orally every 4 h until favorable cervix was achieved. Main outcome measures included success rate of termination within 12, 24, 36 and 48 h, mean induction to delivery time and maternal side-effects. Results: The success rates of termination within 12, 24, 36, 48 h were 50.8%, 84.1%, 88.9% and 92.1%, respectively. Mean induction to delivery time in cases of delivery within 48 h was 13.2 ± 8.4 h, range 2.25-22.9 h. The most common maternal side-effect was chill (33.3%). No serious maternal complication was detected. Conclusion: 400 μg oral misoprostol every 4 h is effective for pregnancy termination in cases of intrauterine fetal death and may be an alternative regimen because of its ease and convenience. 2014-08-30T02:35:43Z 2014-08-30T02:35:43Z 2004 Article 13418076 10.1111/j.1447-0756.2004.00184.x 15210046 JOGRF http://www.scopus.com/inward/record.url?eid=2-s2.0-3042831727&partnerID=40&md5=f2fa279ceffb40515db5cbfc27bb2780 http://www.ncbi.nlm.nih.gov/pubmed/15210046 http://cmuir.cmu.ac.th/handle/6653943832/4140 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objective: To assess the efficacy and maternal side-effects of oral misoprostol for second trimester termination of pregnancies with intrauterine fetal death. Methods: A prospective descriptive study was conducted on 63 pregnant women who had intrauterine fetal death with unfavorable cervix (Bishop scores ≤4). All received 400 μg of misoprostol orally every 4 h until favorable cervix was achieved. Main outcome measures included success rate of termination within 12, 24, 36 and 48 h, mean induction to delivery time and maternal side-effects. Results: The success rates of termination within 12, 24, 36, 48 h were 50.8%, 84.1%, 88.9% and 92.1%, respectively. Mean induction to delivery time in cases of delivery within 48 h was 13.2 ± 8.4 h, range 2.25-22.9 h. The most common maternal side-effect was chill (33.3%). No serious maternal complication was detected. Conclusion: 400 μg oral misoprostol every 4 h is effective for pregnancy termination in cases of intrauterine fetal death and may be an alternative regimen because of its ease and convenience.
format Article
author Pongsatha S.
Tongsong T.
spellingShingle Pongsatha S.
Tongsong T.
Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol
author_facet Pongsatha S.
Tongsong T.
author_sort Pongsatha S.
title Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol
title_short Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol
title_full Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol
title_fullStr Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol
title_full_unstemmed Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol
title_sort therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-3042831727&partnerID=40&md5=f2fa279ceffb40515db5cbfc27bb2780
http://www.ncbi.nlm.nih.gov/pubmed/15210046
http://cmuir.cmu.ac.th/handle/6653943832/4140
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