Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis

© 2016 The Author(s) Objective To estimate the number of people living in Thailand with chronic hepatitis B (CHB), a major cause of liver cirrhosis and cancer, in view of the implementation of programs to prevent CHB complications. Methods Using PubMed/Medline and ScienceDirect, all studies reportin...

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Main Authors: Leroi C., Adam P., Khamduang W., Kawilapat S., Ngo-Giang-Huong N., Ongwandee S., Jiamsiri S., Jourdain G.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84987920178&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41490
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-414902017-09-28T04:21:38Z Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis Leroi C. Adam P. Khamduang W. Kawilapat S. Ngo-Giang-Huong N. Ongwandee S. Jiamsiri S. Jourdain G. © 2016 The Author(s) Objective To estimate the number of people living in Thailand with chronic hepatitis B (CHB), a major cause of liver cirrhosis and cancer, in view of the implementation of programs to prevent CHB complications. Methods Using PubMed/Medline and ScienceDirect, all studies reporting hepatitis B surface antigen (HBsAg) seroprevalence estimates conducted in Thailand and published between 1975 and 2015 were reviewed systematically. Pooled prevalence estimates and their 95% confidence intervals (CIs) were calculated, and potential sources of heterogeneity investigated. Results A high heterogeneity was observed between prevalence estimates. There was a significant decrease in the 150 estimates of HBsAg prevalence with more recent decades of birth (p  <  0.001), even before the implementation of the national universal immunization program in 1992. When restricted to the general population, the pooled prevalence estimate was 5.1% (95% CI 4.3–6.0%), which would translate to an estimated number of individuals with CHB living in Thailand in 2015 as high as three million. Conclusions The high burden of CHB in Asian countries is a major challenge for the incorporation of national programs to prevent CHB complications within health care systems. 2017-09-28T04:21:38Z 2017-09-28T04:21:38Z 2016-10-01 Journal 12019712 2-s2.0-84987920178 10.1016/j.ijid.2016.08.017 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84987920178&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41490
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2016 The Author(s) Objective To estimate the number of people living in Thailand with chronic hepatitis B (CHB), a major cause of liver cirrhosis and cancer, in view of the implementation of programs to prevent CHB complications. Methods Using PubMed/Medline and ScienceDirect, all studies reporting hepatitis B surface antigen (HBsAg) seroprevalence estimates conducted in Thailand and published between 1975 and 2015 were reviewed systematically. Pooled prevalence estimates and their 95% confidence intervals (CIs) were calculated, and potential sources of heterogeneity investigated. Results A high heterogeneity was observed between prevalence estimates. There was a significant decrease in the 150 estimates of HBsAg prevalence with more recent decades of birth (p  <  0.001), even before the implementation of the national universal immunization program in 1992. When restricted to the general population, the pooled prevalence estimate was 5.1% (95% CI 4.3–6.0%), which would translate to an estimated number of individuals with CHB living in Thailand in 2015 as high as three million. Conclusions The high burden of CHB in Asian countries is a major challenge for the incorporation of national programs to prevent CHB complications within health care systems.
format Journal
author Leroi C.
Adam P.
Khamduang W.
Kawilapat S.
Ngo-Giang-Huong N.
Ongwandee S.
Jiamsiri S.
Jourdain G.
spellingShingle Leroi C.
Adam P.
Khamduang W.
Kawilapat S.
Ngo-Giang-Huong N.
Ongwandee S.
Jiamsiri S.
Jourdain G.
Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis
author_facet Leroi C.
Adam P.
Khamduang W.
Kawilapat S.
Ngo-Giang-Huong N.
Ongwandee S.
Jiamsiri S.
Jourdain G.
author_sort Leroi C.
title Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis
title_short Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis
title_full Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis
title_fullStr Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis
title_full_unstemmed Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis
title_sort prevalence of chronic hepatitis b virus infection in thailand: a systematic review and meta-analysis
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84987920178&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41490
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