Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand

In 2008, the Pre-exposure Prophylaxis Initiative (iPrEx) study expanded to include men who have sex with men (MSM) in Chiang Mai, Thailand. In full, 114 participants from Chiang Mai joined this international double-blinded trial of daily FTC-TDF (Truvada®) or placebo as a pre-exposure prophylaxis (P...

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Main Authors: Tangmunkongvorakul A., Chariyalertsak S., Rivet Amico K., Saokhieo P., Wannalak V., Sangangamsakun T., Goicochea P., Grant R.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84880513142&partnerID=40&md5=6c2b22808caf04a6e0cb7eef12cdcb5a
http://cmuir.cmu.ac.th/handle/6653943832/4150
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-41502014-08-30T02:35:44Z Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand Tangmunkongvorakul A. Chariyalertsak S. Rivet Amico K. Saokhieo P. Wannalak V. Sangangamsakun T. Goicochea P. Grant R. In 2008, the Pre-exposure Prophylaxis Initiative (iPrEx) study expanded to include men who have sex with men (MSM) in Chiang Mai, Thailand. In full, 114 participants from Chiang Mai joined this international double-blinded trial of daily FTC-TDF (Truvada®) or placebo as a pre-exposure prophylaxis (PrEP) HIV prevention strategy. To better understand the characteristics of iPrEx participants specifically from this underserved population in Thailand, and gain insights into their experiences of trying to take a daily tablet as part of this blinded PrEP trial, we conducted a qualitative study. In 2010, 32 MSM iPrEx participants provided in-depth interviews and an additional 14 joined focus group discussions. Results of the qualitative analyzes suggested that participants held generally positive attitudes toward the iPrEx study and study medication and related this to high rates of adherence to the daily regimen. Participants also reflected on the provision of quality health care as part of participation in the trial, as well as support from clinical research staff, family and friends as helpful in supporting high rates of study medication adherence. Discourse concerning challenges to adherence included medication taking behavior, which was contextualized by lifestyle, living arrangement, social life, social stigma in terms of being mistakenly identified as HIV positive or unintentional disclosure of sexual identity to family and friends, and relationship conflicts with partners. The results provide broader perspectives of participant experiences of the study medication and daily adherence in the larger contexts of the MSM community, close relationships, and the study climate, and can be leveraged in constructing PrEP adherence support approaches within these communities. © 2013 Taylor & Francis. 2014-08-30T02:35:44Z 2014-08-30T02:35:44Z 2013 Article 09540121 10.1080/09540121.2012.748871 23252473 AIDCE http://www.scopus.com/inward/record.url?eid=2-s2.0-84880513142&partnerID=40&md5=6c2b22808caf04a6e0cb7eef12cdcb5a http://cmuir.cmu.ac.th/handle/6653943832/4150 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description In 2008, the Pre-exposure Prophylaxis Initiative (iPrEx) study expanded to include men who have sex with men (MSM) in Chiang Mai, Thailand. In full, 114 participants from Chiang Mai joined this international double-blinded trial of daily FTC-TDF (Truvada®) or placebo as a pre-exposure prophylaxis (PrEP) HIV prevention strategy. To better understand the characteristics of iPrEx participants specifically from this underserved population in Thailand, and gain insights into their experiences of trying to take a daily tablet as part of this blinded PrEP trial, we conducted a qualitative study. In 2010, 32 MSM iPrEx participants provided in-depth interviews and an additional 14 joined focus group discussions. Results of the qualitative analyzes suggested that participants held generally positive attitudes toward the iPrEx study and study medication and related this to high rates of adherence to the daily regimen. Participants also reflected on the provision of quality health care as part of participation in the trial, as well as support from clinical research staff, family and friends as helpful in supporting high rates of study medication adherence. Discourse concerning challenges to adherence included medication taking behavior, which was contextualized by lifestyle, living arrangement, social life, social stigma in terms of being mistakenly identified as HIV positive or unintentional disclosure of sexual identity to family and friends, and relationship conflicts with partners. The results provide broader perspectives of participant experiences of the study medication and daily adherence in the larger contexts of the MSM community, close relationships, and the study climate, and can be leveraged in constructing PrEP adherence support approaches within these communities. © 2013 Taylor & Francis.
format Article
author Tangmunkongvorakul A.
Chariyalertsak S.
Rivet Amico K.
Saokhieo P.
Wannalak V.
Sangangamsakun T.
Goicochea P.
Grant R.
spellingShingle Tangmunkongvorakul A.
Chariyalertsak S.
Rivet Amico K.
Saokhieo P.
Wannalak V.
Sangangamsakun T.
Goicochea P.
Grant R.
Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
author_facet Tangmunkongvorakul A.
Chariyalertsak S.
Rivet Amico K.
Saokhieo P.
Wannalak V.
Sangangamsakun T.
Goicochea P.
Grant R.
author_sort Tangmunkongvorakul A.
title Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_short Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_full Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_fullStr Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_full_unstemmed Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_sort facilitators and barriers to medication adherence in an hiv prevention study among men who have sex with men in the iprex study in chiang mai, thailand
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84880513142&partnerID=40&md5=6c2b22808caf04a6e0cb7eef12cdcb5a
http://cmuir.cmu.ac.th/handle/6653943832/4150
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