6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone induces caspase-8- and -9-mediated apoptosis in human cancer cells

• Main Authors: Banjerdpongchai R., Khaw-on P., Ristee C., Pompimon W.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84880301349&partnerID=40&md5=397c259c6ac703da8a16ff6b77b0d496; http://cmuir.cmu.ac.th/handle/6653943832/4157
• Institution: Chiang Mai University

6,8-Dihydroxy-7-methoxy-1-methyl-azafluorenone (DMMA), a purified compound from Polyalthia cerasoides roots, is cytotoxic to various cancer cell lines. The aims of this study were to demonstrate the type of cancer cell death and the mechanism(s) involved. DMMA inhibited cell growth and induced apopt...