Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178

© 2016 The American Chemical Society and American Society of Pharmacognosy. Three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin K (6), and α,β-dehydro-4a,5-dihydromonacolin L (7),...

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Main Authors: Phainuphong P., Rukachaisirikul V., Saithong S., Phongpaichit S., Bowornwiriyapan K., Muanprasat C., Srimaroeng C., Duangjai A., Sakayaroj J.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84976319210&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41795
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-417952017-09-28T04:23:26Z Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178 Phainuphong P. Rukachaisirikul V. Saithong S. Phongpaichit S. Bowornwiriyapan K. Muanprasat C. Srimaroeng C. Duangjai A. Sakayaroj J. © 2016 The American Chemical Society and American Society of Pharmacognosy. Three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin K (6), and α,β-dehydro-4a,5-dihydromonacolin L (7), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. Their structures were established using spectroscopic evidence. Compound 5 exhibited the most potent activity against HMG-CoA reductase, with an IC 50 value of 387 μM. In addition, the present study indicated the direct interaction of compound 5 with HMG-CoA reductase. Compound 5 was considered to be noncytotoxic against noncancerous Vero cells, with an IC 50 value of 40.0 μM, whereas compound 2 displayed much stronger activity, with an IC 50 value of 2.2 μM. 2017-09-28T04:23:26Z 2017-09-28T04:23:26Z 2016-06-24 Journal 01633864 2-s2.0-84976319210 10.1021/acs.jnatprod.5b00961 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84976319210&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41795
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2016 The American Chemical Society and American Society of Pharmacognosy. Three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin K (6), and α,β-dehydro-4a,5-dihydromonacolin L (7), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. Their structures were established using spectroscopic evidence. Compound 5 exhibited the most potent activity against HMG-CoA reductase, with an IC 50 value of 387 μM. In addition, the present study indicated the direct interaction of compound 5 with HMG-CoA reductase. Compound 5 was considered to be noncytotoxic against noncancerous Vero cells, with an IC 50 value of 40.0 μM, whereas compound 2 displayed much stronger activity, with an IC 50 value of 2.2 μM.
format Journal
author Phainuphong P.
Rukachaisirikul V.
Saithong S.
Phongpaichit S.
Bowornwiriyapan K.
Muanprasat C.
Srimaroeng C.
Duangjai A.
Sakayaroj J.
spellingShingle Phainuphong P.
Rukachaisirikul V.
Saithong S.
Phongpaichit S.
Bowornwiriyapan K.
Muanprasat C.
Srimaroeng C.
Duangjai A.
Sakayaroj J.
Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
author_facet Phainuphong P.
Rukachaisirikul V.
Saithong S.
Phongpaichit S.
Bowornwiriyapan K.
Muanprasat C.
Srimaroeng C.
Duangjai A.
Sakayaroj J.
author_sort Phainuphong P.
title Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
title_short Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
title_full Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
title_fullStr Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
title_full_unstemmed Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
title_sort lovastatin analogues from the soil-derived fungus aspergillus sclerotiorum psu-rspg178
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84976319210&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41795
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