Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors
© 2016, The Japanese Society of Hematology. In the present study, we sought to determine the prevalence of iron overload in patients with non-transfusion-dependent thalassemia (NTDT) and its association with genotype and other clinical risk factors, and to evaluate the correlation between serum ferr...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Journal |
Published: |
2017
|
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84962706226&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41815 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-41815 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-418152017-09-28T04:23:33Z Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors Tantiworawit A. Charoenkwan P. Hantrakool S. Choeyprasert W. Sivasomboon C. Sanguansermsri T. © 2016, The Japanese Society of Hematology. In the present study, we sought to determine the prevalence of iron overload in patients with non-transfusion-dependent thalassemia (NTDT) and its association with genotype and other clinical risk factors, and to evaluate the correlation between serum ferritin (SF) and liver iron concentration (LIC). Myocardial and liver iron concentration was measured by MRI using a T2* gradient multi-echo sequence in NTDT patients, aged 10–50 years. Of 91 patients, 54 (59 %) had hepatic iron overload. None had cardiac iron overload. The clinical risk factors for hepatic iron overload were age > 20 years (adjusted OR 30.2, 95 % CI 4.5–203, p < 0.001), hemoglobin level < 7 g/dL (adjusted OR 6.3, 95 % CI 1.01–39.5, p = 0.049), and cumulative RBC transfusion > 10 units (adjusted OR 53.6, 95 % CI 3.2–884, p = 0.005). Beta-thalassemia genotype was associated with higher risk of iron overload by univariate analysis, but the association was not significant when adjusted for other clinical factors. The correlation coefficient between SF and LIC was 0.60 (p < 0.001). In conclusion, the prevalence of hepatic iron overload is high in NTDT. Older age, lower hemoglobin level, and higher cumulative RBC transfusion are significant risk factors. SF and LIC show a significant positive correlation. 2017-09-28T04:23:33Z 2017-09-28T04:23:33Z 2016-06-01 Journal 09255710 2-s2.0-84962706226 10.1007/s12185-016-1991-5 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84962706226&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41815 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
description |
© 2016, The Japanese Society of Hematology. In the present study, we sought to determine the prevalence of iron overload in patients with non-transfusion-dependent thalassemia (NTDT) and its association with genotype and other clinical risk factors, and to evaluate the correlation between serum ferritin (SF) and liver iron concentration (LIC). Myocardial and liver iron concentration was measured by MRI using a T2* gradient multi-echo sequence in NTDT patients, aged 10–50 years. Of 91 patients, 54 (59 %) had hepatic iron overload. None had cardiac iron overload. The clinical risk factors for hepatic iron overload were age > 20 years (adjusted OR 30.2, 95 % CI 4.5–203, p < 0.001), hemoglobin level < 7 g/dL (adjusted OR 6.3, 95 % CI 1.01–39.5, p = 0.049), and cumulative RBC transfusion > 10 units (adjusted OR 53.6, 95 % CI 3.2–884, p = 0.005). Beta-thalassemia genotype was associated with higher risk of iron overload by univariate analysis, but the association was not significant when adjusted for other clinical factors. The correlation coefficient between SF and LIC was 0.60 (p < 0.001). In conclusion, the prevalence of hepatic iron overload is high in NTDT. Older age, lower hemoglobin level, and higher cumulative RBC transfusion are significant risk factors. SF and LIC show a significant positive correlation. |
format |
Journal |
author |
Tantiworawit A. Charoenkwan P. Hantrakool S. Choeyprasert W. Sivasomboon C. Sanguansermsri T. |
spellingShingle |
Tantiworawit A. Charoenkwan P. Hantrakool S. Choeyprasert W. Sivasomboon C. Sanguansermsri T. Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors |
author_facet |
Tantiworawit A. Charoenkwan P. Hantrakool S. Choeyprasert W. Sivasomboon C. Sanguansermsri T. |
author_sort |
Tantiworawit A. |
title |
Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors |
title_short |
Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors |
title_full |
Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors |
title_fullStr |
Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors |
title_full_unstemmed |
Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors |
title_sort |
iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors |
publishDate |
2017 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84962706226&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41815 |
_version_ |
1681422072120606720 |