Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients

© Cambridge University Press 2016. Purpose: To compare intensity-modulated radiation therapy (IMRT) treatment planning between using positron emission tomography/computed tomography (PET/CT) and CT for target volume delineation in patients with non-small cell lung cancer (NSCLC). Methods: Nine NSCLC...

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Main Authors: Sangudsup S., Kaewchur T., Teeyasoontranon W., Klunklin P., Chawapun N., Ua-Apisitwong S.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84964319602&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41824
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-418242017-09-28T04:23:34Z Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients Sangudsup S. Kaewchur T. Teeyasoontranon W. Klunklin P. Chawapun N. Ua-Apisitwong S. © Cambridge University Press 2016. Purpose: To compare intensity-modulated radiation therapy (IMRT) treatment planning between using positron emission tomography/computed tomography (PET/CT) and CT for target volume delineation in patients with non-small cell lung cancer (NSCLC). Methods: Nine NSCLC patients with PET/CT images were enrolled into this study. Gross tumour volumes (GTVs) were delineated by the PET visual assessment (PETvis), the automated PET (PETauto), standardised uptake value (SUV) > 2·5 (PET2·5) and threshold 40% SUVmax (PET40), and CT-based method. For each patient, two IMRT treatment plans based on CT and PET/CT delineation were performed. The target coverage and the dose-volume parameters for organs at risk were analysed. Results: The PETauto referred to PET40 when SUVmax < 7 and PET2·5 when SUVmax≥7. The mean GTVs were 15·04, 15·7 and 15·14 cc for PETauto, PETvis and CT based, respectively. The GTV of PETauto was not different from PETvis (p = 0·441) and CT based (p = 0·594). Based on CT delineation in IMRT planning, only 34% of the cases had sufficient PET/CT planning target volumes coverage, whereas the organs at risk dose parameters were not statistically significant (p > 0·05). Conclusions: PET/CT enables more accurate assessment of tumour delineation for NSCLC, therefore improve target coverage in IMRT plan. 2017-09-28T04:23:33Z 2017-09-28T04:23:33Z 2016-06-01 Journal 14603969 2-s2.0-84964319602 10.1017/S1460396916000078 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84964319602&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41824
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © Cambridge University Press 2016. Purpose: To compare intensity-modulated radiation therapy (IMRT) treatment planning between using positron emission tomography/computed tomography (PET/CT) and CT for target volume delineation in patients with non-small cell lung cancer (NSCLC). Methods: Nine NSCLC patients with PET/CT images were enrolled into this study. Gross tumour volumes (GTVs) were delineated by the PET visual assessment (PETvis), the automated PET (PETauto), standardised uptake value (SUV) > 2·5 (PET2·5) and threshold 40% SUVmax (PET40), and CT-based method. For each patient, two IMRT treatment plans based on CT and PET/CT delineation were performed. The target coverage and the dose-volume parameters for organs at risk were analysed. Results: The PETauto referred to PET40 when SUVmax < 7 and PET2·5 when SUVmax≥7. The mean GTVs were 15·04, 15·7 and 15·14 cc for PETauto, PETvis and CT based, respectively. The GTV of PETauto was not different from PETvis (p = 0·441) and CT based (p = 0·594). Based on CT delineation in IMRT planning, only 34% of the cases had sufficient PET/CT planning target volumes coverage, whereas the organs at risk dose parameters were not statistically significant (p > 0·05). Conclusions: PET/CT enables more accurate assessment of tumour delineation for NSCLC, therefore improve target coverage in IMRT plan.
format Journal
author Sangudsup S.
Kaewchur T.
Teeyasoontranon W.
Klunklin P.
Chawapun N.
Ua-Apisitwong S.
spellingShingle Sangudsup S.
Kaewchur T.
Teeyasoontranon W.
Klunklin P.
Chawapun N.
Ua-Apisitwong S.
Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients
author_facet Sangudsup S.
Kaewchur T.
Teeyasoontranon W.
Klunklin P.
Chawapun N.
Ua-Apisitwong S.
author_sort Sangudsup S.
title Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients
title_short Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients
title_full Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients
title_fullStr Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients
title_full_unstemmed Volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (PET/CT) and CT images for target delineation in non-small cell lung cancer patients
title_sort volumetric and dosimetric comparison of computerised radiotherapy treatment plan between using positron emission tomography/computed tomography (pet/ct) and ct images for target delineation in non-small cell lung cancer patients
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84964319602&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41824
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