Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats
© 2016 Taylor & Francis Group, LLC. Oryza sativa L. var. indica cv. Kum Doi Saket is a pigmented rice variety grown in northern Thailand. Our previous study found that the methanol extract of purple rice seed had the highest level of antimutagenicity in a Salmonella mutation assay. The present...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Journal |
Published: |
2017
|
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84966727858&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41878 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-41878 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-418782017-09-28T04:23:54Z Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats Punvittayagul C. Sankam P. Taya S. Wongpoomchai R. © 2016 Taylor & Francis Group, LLC. Oryza sativa L. var. indica cv. Kum Doi Saket is a pigmented rice variety grown in northern Thailand. Our previous study found that the methanol extract of purple rice seed had the highest level of antimutagenicity in a Salmonella mutation assay. The present study was designed to evaluate its in vivo anticlastogenic and anticarcinogenic potentials. The purple rice extract had no acute toxicity on rats. The oral administration of 1,000 mg/kg body weight (bw) of the extract for 28 days did not increase the number of micronucleated hepatocytes. Interestingly, it significantly reduced the amount of micronucleus formation in the liver of diethylnitrosamine (DEN)-treated rats. The inhibitory mechanism involved the induction of hepatic glutathione S-transferase (GST) activity. In addition, oral administration of 500 mg/kg bw extract for 10 weeks significantly decreased the number of hepatic GST placental form positive foci, but did not modulate the number of colonic aberrant crypt foci in DEN- and dimethylhydrazine-initiated rats. In conclusion, the methanol extract of purple rice seed showed no toxicity, clastogenicity, or carcinogenicity in laboratory rats. It did display chemopreventive activity against the early stages of rat hepatocarcinogenesis. 2017-09-28T04:23:54Z 2017-09-28T04:23:54Z 2016-05-18 Journal 01635581 2-s2.0-84966727858 10.1080/01635581.2016.1158289 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84966727858&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41878 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
description |
© 2016 Taylor & Francis Group, LLC. Oryza sativa L. var. indica cv. Kum Doi Saket is a pigmented rice variety grown in northern Thailand. Our previous study found that the methanol extract of purple rice seed had the highest level of antimutagenicity in a Salmonella mutation assay. The present study was designed to evaluate its in vivo anticlastogenic and anticarcinogenic potentials. The purple rice extract had no acute toxicity on rats. The oral administration of 1,000 mg/kg body weight (bw) of the extract for 28 days did not increase the number of micronucleated hepatocytes. Interestingly, it significantly reduced the amount of micronucleus formation in the liver of diethylnitrosamine (DEN)-treated rats. The inhibitory mechanism involved the induction of hepatic glutathione S-transferase (GST) activity. In addition, oral administration of 500 mg/kg bw extract for 10 weeks significantly decreased the number of hepatic GST placental form positive foci, but did not modulate the number of colonic aberrant crypt foci in DEN- and dimethylhydrazine-initiated rats. In conclusion, the methanol extract of purple rice seed showed no toxicity, clastogenicity, or carcinogenicity in laboratory rats. It did display chemopreventive activity against the early stages of rat hepatocarcinogenesis. |
format |
Journal |
author |
Punvittayagul C. Sankam P. Taya S. Wongpoomchai R. |
spellingShingle |
Punvittayagul C. Sankam P. Taya S. Wongpoomchai R. Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats |
author_facet |
Punvittayagul C. Sankam P. Taya S. Wongpoomchai R. |
author_sort |
Punvittayagul C. |
title |
Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats |
title_short |
Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats |
title_full |
Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats |
title_fullStr |
Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats |
title_full_unstemmed |
Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats |
title_sort |
anticlastogenicity and anticarcinogenicity of purple rice extract in rats |
publishDate |
2017 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84966727858&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41878 |
_version_ |
1681422083774480384 |