Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises

© 2016, American College of Rheumatology. Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exe...

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Main Authors: De Lautour H., Taylor W., Adebajo A., Alten R., Burgos-Vargas R., Chapman P., Cimmino M., Da Rocha Castelar Pinheiro G., Day R., Harrold L., Helliwell P., Janssen M., Kerr G., Kavanaugh A., Khanna D., Khanna P., Lin C., Louthrenoo W., McCarthy G., Vazquez-Mellado J., Mikuls T., Neogi T., Ogdie A., Perez-Ruiz F., Schlesinger N., Ralph Schumacher H., Scirè C., Singh J., Sivera F., Slot O., Stamp L., Tausche A., Terkeltaub R., Uhlig T., Van De Laar M., White D., Yamanaka H., Zeng X., Dalbeth N.
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Published: 2017
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/41940
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spelling th-cmuir.6653943832-419402017-09-28T04:24:18Z Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises De Lautour H. Taylor W. Adebajo A. Alten R. Burgos-Vargas R. Chapman P. Cimmino M. Da Rocha Castelar Pinheiro G. Day R. Harrold L. Helliwell P. Janssen M. Kerr G. Kavanaugh A. Khanna D. Khanna P. Lin C. Louthrenoo W. McCarthy G. Vazquez-Mellado J. Mikuls T. Neogi T. Ogdie A. Perez-Ruiz F. Schlesinger N. Ralph Schumacher H. Scirè C. Singh J. Sivera F. Slot O. Stamp L. Tausche A. Terkeltaub R. Uhlig T. Van De Laar M. White D. Yamanaka H. Zeng X. Dalbeth N. © 2016, American College of Rheumatology. Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate ( < 0.36 mm), pain ( < 2 on a 10-point scale), and patient global assessment ( < 2 on a 10-point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission, with equal responses for 6 months (51%) and 1 year (49%). In the discrete-choice experiment, there was a preference towards 12 months as a timeframe for remission. Conclusion These consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain, and patient global assessment. These preliminary criteria now require testing in clinical data sets. 2017-09-28T04:24:18Z 2017-09-28T04:24:18Z 2016-05-01 Journal 2151464X 2-s2.0-84964432661 10.1002/acr.22741 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84964432661&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41940
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2016, American College of Rheumatology. Objective To establish consensus for potential remission criteria to use in clinical trials of gout. Methods Experts (n = 88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey, followed by a discrete-choice experiment using 1000Minds software. The exercises focused on identifying domains, definitions for each domain, and the timeframe over which remission should be defined. Results There were 49 respondents (56% response) to the initial survey, with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%), and patient global assessment of disease activity (93%) as measurement domains in remission criteria. Consensus was also reached for domain definitions, including serum urate ( < 0.36 mm), pain ( < 2 on a 10-point scale), and patient global assessment ( < 2 on a 10-point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission, with equal responses for 6 months (51%) and 1 year (49%). In the discrete-choice experiment, there was a preference towards 12 months as a timeframe for remission. Conclusion These consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain, and patient global assessment. These preliminary criteria now require testing in clinical data sets.
format Journal
author De Lautour H.
Taylor W.
Adebajo A.
Alten R.
Burgos-Vargas R.
Chapman P.
Cimmino M.
Da Rocha Castelar Pinheiro G.
Day R.
Harrold L.
Helliwell P.
Janssen M.
Kerr G.
Kavanaugh A.
Khanna D.
Khanna P.
Lin C.
Louthrenoo W.
McCarthy G.
Vazquez-Mellado J.
Mikuls T.
Neogi T.
Ogdie A.
Perez-Ruiz F.
Schlesinger N.
Ralph Schumacher H.
Scirè C.
Singh J.
Sivera F.
Slot O.
Stamp L.
Tausche A.
Terkeltaub R.
Uhlig T.
Van De Laar M.
White D.
Yamanaka H.
Zeng X.
Dalbeth N.
spellingShingle De Lautour H.
Taylor W.
Adebajo A.
Alten R.
Burgos-Vargas R.
Chapman P.
Cimmino M.
Da Rocha Castelar Pinheiro G.
Day R.
Harrold L.
Helliwell P.
Janssen M.
Kerr G.
Kavanaugh A.
Khanna D.
Khanna P.
Lin C.
Louthrenoo W.
McCarthy G.
Vazquez-Mellado J.
Mikuls T.
Neogi T.
Ogdie A.
Perez-Ruiz F.
Schlesinger N.
Ralph Schumacher H.
Scirè C.
Singh J.
Sivera F.
Slot O.
Stamp L.
Tausche A.
Terkeltaub R.
Uhlig T.
Van De Laar M.
White D.
Yamanaka H.
Zeng X.
Dalbeth N.
Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises
author_facet De Lautour H.
Taylor W.
Adebajo A.
Alten R.
Burgos-Vargas R.
Chapman P.
Cimmino M.
Da Rocha Castelar Pinheiro G.
Day R.
Harrold L.
Helliwell P.
Janssen M.
Kerr G.
Kavanaugh A.
Khanna D.
Khanna P.
Lin C.
Louthrenoo W.
McCarthy G.
Vazquez-Mellado J.
Mikuls T.
Neogi T.
Ogdie A.
Perez-Ruiz F.
Schlesinger N.
Ralph Schumacher H.
Scirè C.
Singh J.
Sivera F.
Slot O.
Stamp L.
Tausche A.
Terkeltaub R.
Uhlig T.
Van De Laar M.
White D.
Yamanaka H.
Zeng X.
Dalbeth N.
author_sort De Lautour H.
title Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises
title_short Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises
title_full Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises
title_fullStr Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises
title_full_unstemmed Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises
title_sort development of preliminary remission criteria for gout using delphi and 1000minds consensus exercises
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84964432661&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41940
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