Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata

© 2016 The American Chemical Society and American Society of Pharmacognosy. Five new oxoprotoberberine alkaloids, miliusacunines A-E (1-5), along with nine known compounds, 6-14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spe...

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Main Authors:	Promchai T., Jaidee A., Cheenpracha S., Trisuwan K., Rattanajak R., Kamchonwongpaisan S., Laphookhieo S., Pyne S., Ritthiwigrom T.
Format:	Journal
Published:	2017
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969695160&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41944
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-41944
record_format	dspace
spelling	th-cmuir.6653943832-419442017-09-28T04:24:19Z Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata Promchai T. Jaidee A. Cheenpracha S. Trisuwan K. Rattanajak R. Kamchonwongpaisan S. Laphookhieo S. Pyne S. Ritthiwigrom T. © 2016 The American Chemical Society and American Society of Pharmacognosy. Five new oxoprotoberberine alkaloids, miliusacunines A-E (1-5), along with nine known compounds, 6-14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicities against the KB and Vero cell lines and for antimalarial activities against the Plasmodium falciparum strains TM4 and K1 (a sensitive and a multi-drug-resistant strain, respectively). Compound 1 showed in vitro antimalarial activity against the TM4 strain, with an IC 50 value of 19.3 ± 3.4 μM, and compound 2 demonstrated significant activity against the K1 strain, with an IC 50 value of 10.8 ± 4.1 μM. Both compounds showed no discernible cytotoxicity to the Vero cell line at the concentration levels evaluated. 2017-09-28T04:24:19Z 2017-09-28T04:24:19Z 2016-04-22 Journal 01633864 2-s2.0-84969695160 10.1021/acs.jnatprod.5b01054 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969695160&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41944
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
description	© 2016 The American Chemical Society and American Society of Pharmacognosy. Five new oxoprotoberberine alkaloids, miliusacunines A-E (1-5), along with nine known compounds, 6-14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicities against the KB and Vero cell lines and for antimalarial activities against the Plasmodium falciparum strains TM4 and K1 (a sensitive and a multi-drug-resistant strain, respectively). Compound 1 showed in vitro antimalarial activity against the TM4 strain, with an IC 50 value of 19.3 ± 3.4 μM, and compound 2 demonstrated significant activity against the K1 strain, with an IC 50 value of 10.8 ± 4.1 μM. Both compounds showed no discernible cytotoxicity to the Vero cell line at the concentration levels evaluated.
format	Journal
author	Promchai T. Jaidee A. Cheenpracha S. Trisuwan K. Rattanajak R. Kamchonwongpaisan S. Laphookhieo S. Pyne S. Ritthiwigrom T.
spellingShingle	Promchai T. Jaidee A. Cheenpracha S. Trisuwan K. Rattanajak R. Kamchonwongpaisan S. Laphookhieo S. Pyne S. Ritthiwigrom T. Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
author_facet	Promchai T. Jaidee A. Cheenpracha S. Trisuwan K. Rattanajak R. Kamchonwongpaisan S. Laphookhieo S. Pyne S. Ritthiwigrom T.
author_sort	Promchai T.
title	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_short	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_full	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_fullStr	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_full_unstemmed	Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata
title_sort	antimalarial oxoprotoberberine alkaloids from the leaves of miliusa cuneata
publishDate	2017
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969695160&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41944
_version_	1681422096224223232

Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata

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