Potential roles of fibroblast growth factor 21 in the brain

© 2016, Springer Science+Business Media New York. Fibroblast growth factor 21 (FGF21) is an endocrine hormone, playing an important role in the regulation of metabolism. FGF21 is primarily expressed by several tissues, including liver, pancreas, thymus, heart, muscle, adipose tissue, and brain. In a...

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Main Authors: Sa-nguanmoo P., Chattipakorn N., Chattipakorn S.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961139342&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41965
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-419652017-09-28T04:24:26Z Potential roles of fibroblast growth factor 21 in the brain Sa-nguanmoo P. Chattipakorn N. Chattipakorn S. © 2016, Springer Science+Business Media New York. Fibroblast growth factor 21 (FGF21) is an endocrine hormone, playing an important role in the regulation of metabolism. FGF21 is primarily expressed by several tissues, including liver, pancreas, thymus, heart, muscle, adipose tissue, and brain. In addition to the effects of FGF21 in lowering glucose and lipid levels, increasing insulin sensitivity and regulating energy homeostasis in rodents and non-human primate models of diabetes and obesity, previous reports have demonstrated that FGF21 also plays an important role in the brain involving it in potential effects in metabolic regulation, neuroprotection and cognition. In this review, the current available evidence from both in vitro and in vivo investigations regarding the roles of FGF21 and its function in the brain are comprehensively summarized. In addition, the mechanistic insights regarding the roles of FGF21 in the brain and its potential neuroprotective benefits are also presented and discussed. 2017-09-28T04:24:26Z 2017-09-28T04:24:26Z 2016-04-01 Journal 08857490 2-s2.0-84961139342 10.1007/s11011-015-9789-3 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961139342&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41965
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2016, Springer Science+Business Media New York. Fibroblast growth factor 21 (FGF21) is an endocrine hormone, playing an important role in the regulation of metabolism. FGF21 is primarily expressed by several tissues, including liver, pancreas, thymus, heart, muscle, adipose tissue, and brain. In addition to the effects of FGF21 in lowering glucose and lipid levels, increasing insulin sensitivity and regulating energy homeostasis in rodents and non-human primate models of diabetes and obesity, previous reports have demonstrated that FGF21 also plays an important role in the brain involving it in potential effects in metabolic regulation, neuroprotection and cognition. In this review, the current available evidence from both in vitro and in vivo investigations regarding the roles of FGF21 and its function in the brain are comprehensively summarized. In addition, the mechanistic insights regarding the roles of FGF21 in the brain and its potential neuroprotective benefits are also presented and discussed.
format Journal
author Sa-nguanmoo P.
Chattipakorn N.
Chattipakorn S.
spellingShingle Sa-nguanmoo P.
Chattipakorn N.
Chattipakorn S.
Potential roles of fibroblast growth factor 21 in the brain
author_facet Sa-nguanmoo P.
Chattipakorn N.
Chattipakorn S.
author_sort Sa-nguanmoo P.
title Potential roles of fibroblast growth factor 21 in the brain
title_short Potential roles of fibroblast growth factor 21 in the brain
title_full Potential roles of fibroblast growth factor 21 in the brain
title_fullStr Potential roles of fibroblast growth factor 21 in the brain
title_full_unstemmed Potential roles of fibroblast growth factor 21 in the brain
title_sort potential roles of fibroblast growth factor 21 in the brain
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961139342&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41965
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