Potential Roles of Humanin on Apoptosis in the Heart

© 2016 John Wiley & Sons Ltd. The process of programmed cell death, or apoptosis, is known as a key player in the development and progression of cardiovascular disease. The proposed mechanism for apoptosis is the activation of two main apoptotic signaling pathways (the extrinsic and intrinsic...

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Main Authors: Charununtakorn S., Shinlapawittayatorn K., Chattipakorn S., Chattipakorn N.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84959298605&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41973
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-419732017-09-28T04:24:32Z Potential Roles of Humanin on Apoptosis in the Heart Charununtakorn S. Shinlapawittayatorn K. Chattipakorn S. Chattipakorn N. © 2016 John Wiley & Sons Ltd. The process of programmed cell death, or apoptosis, is known as a key player in the development and progression of cardiovascular disease. The proposed mechanism for apoptosis is the activation of two main apoptotic signaling pathways (the extrinsic and intrinsic pathways), which lead to cell death. As the rate and amount of cardiomyocyte loss is the most important determinant of patient morbidity and mortality, novel treatment strategies targeting apoptosis are crucial. Recently, Humanin has been shown to exert protective effects against cellular apoptosis in both experimental and clinical studies. The potential cardioprotective mechanisms of Humanin have been shown to involve both the extracellular and intracellular signaling pathways. In this review, the current knowledge and the mechanisms inhibiting cellular apoptosis by Humanin during cardiac injury are comprehensively summarized. In addition, both research and clinical findings regarding the effects of Humanin on the heart and vasculature are also presented and discussed. Currently available information suggests that Humanin may exert cardioprotective benefits and could potentially be used as a novel pharmacological intervention against cellular apoptosis during myocardial injury. 2017-09-28T04:24:32Z 2017-09-28T04:24:32Z 2016-04-01 Journal 17555914 2-s2.0-84959298605 10.1111/1755-5922.12168 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84959298605&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/41973
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2016 John Wiley & Sons Ltd. The process of programmed cell death, or apoptosis, is known as a key player in the development and progression of cardiovascular disease. The proposed mechanism for apoptosis is the activation of two main apoptotic signaling pathways (the extrinsic and intrinsic pathways), which lead to cell death. As the rate and amount of cardiomyocyte loss is the most important determinant of patient morbidity and mortality, novel treatment strategies targeting apoptosis are crucial. Recently, Humanin has been shown to exert protective effects against cellular apoptosis in both experimental and clinical studies. The potential cardioprotective mechanisms of Humanin have been shown to involve both the extracellular and intracellular signaling pathways. In this review, the current knowledge and the mechanisms inhibiting cellular apoptosis by Humanin during cardiac injury are comprehensively summarized. In addition, both research and clinical findings regarding the effects of Humanin on the heart and vasculature are also presented and discussed. Currently available information suggests that Humanin may exert cardioprotective benefits and could potentially be used as a novel pharmacological intervention against cellular apoptosis during myocardial injury.
format Journal
author Charununtakorn S.
Shinlapawittayatorn K.
Chattipakorn S.
Chattipakorn N.
spellingShingle Charununtakorn S.
Shinlapawittayatorn K.
Chattipakorn S.
Chattipakorn N.
Potential Roles of Humanin on Apoptosis in the Heart
author_facet Charununtakorn S.
Shinlapawittayatorn K.
Chattipakorn S.
Chattipakorn N.
author_sort Charununtakorn S.
title Potential Roles of Humanin on Apoptosis in the Heart
title_short Potential Roles of Humanin on Apoptosis in the Heart
title_full Potential Roles of Humanin on Apoptosis in the Heart
title_fullStr Potential Roles of Humanin on Apoptosis in the Heart
title_full_unstemmed Potential Roles of Humanin on Apoptosis in the Heart
title_sort potential roles of humanin on apoptosis in the heart
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84959298605&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/41973
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