Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database

Context: Traditional medicines have long been used by Thai practitioners for the treatment of many diseases including hypertension. The antihypertensive recipes and plants were searched and selected by a computer program from Thai/Lanna medicinal plant recipe database "MANOSROI III" using...

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Main Authors: Manosroi A., Lohcharoenkal W., Khonsung P., Manosroi W., Manosroi J.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84885614367&partnerID=40&md5=8c1753b1bababa18d550d3be95fa71e2
http://cmuir.cmu.ac.th/handle/6653943832/4199
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-41992014-08-30T02:35:47Z Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database Manosroi A. Lohcharoenkal W. Khonsung P. Manosroi W. Manosroi J. Context: Traditional medicines have long been used by Thai practitioners for the treatment of many diseases including hypertension. The antihypertensive recipes and plants were searched and selected by a computer program from Thai/Lanna medicinal plant recipe database "MANOSROI III" using hypertensive symptoms as keywords. Objectives: To evaluate the antihypertensive potential of 30 recipes and 10 Thai-Lanna medicinal plants selected from "MANOSROI III" database using l-NAME induced hypertensive rat model. Materials and methods: Extracts from the selected recipes and plants were prepared according to the traditional indications. Antihypertensive activities including the decrease of the mean arterial blood pressure (MABP) and heart rate (HR) of the extracts as well as duration of action were investigated by intra-arterial assessment technique. All extracts were screened for phytochemicals including anthraquinone, glycoside, xanthone, tannin, carotenoid, flavones and alkaloids using standard methods. Results and conclusions: All 12 of the 30 selected recipes (40%) demonstrated antihypertensive activity with the maximum decrease of MABP at 27.17±3.17% that was 2.41-fold of prazosin hydrochloride. Most recipes exhibiting antihypertensive activity contained plants in the families of Zingiberaceae and Piperaceae. The top five antihypertensive recipes showed the presence of glycosides, xanthones and alkaloids. Ten single plants from these recipes were extracted and evaluated for antihypertensive activity. The cassumunar ginger extract exhibited the maximum decrease of MABP at 39.83±3.92%, which was 3.54-times that of prazosin hydrochloride. This study demonstrated the potent antihypertensive activity of Thai medicinal plants and recipes that can be further developed as antihypertensive agents. © 2013 Informa Healthcare USA, Inc. 2014-08-30T02:35:47Z 2014-08-30T02:35:47Z 2013 Article 13880209 10.3109/13880209.2013.796391 PHBIF http://www.scopus.com/inward/record.url?eid=2-s2.0-84885614367&partnerID=40&md5=8c1753b1bababa18d550d3be95fa71e2 http://cmuir.cmu.ac.th/handle/6653943832/4199 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Context: Traditional medicines have long been used by Thai practitioners for the treatment of many diseases including hypertension. The antihypertensive recipes and plants were searched and selected by a computer program from Thai/Lanna medicinal plant recipe database "MANOSROI III" using hypertensive symptoms as keywords. Objectives: To evaluate the antihypertensive potential of 30 recipes and 10 Thai-Lanna medicinal plants selected from "MANOSROI III" database using l-NAME induced hypertensive rat model. Materials and methods: Extracts from the selected recipes and plants were prepared according to the traditional indications. Antihypertensive activities including the decrease of the mean arterial blood pressure (MABP) and heart rate (HR) of the extracts as well as duration of action were investigated by intra-arterial assessment technique. All extracts were screened for phytochemicals including anthraquinone, glycoside, xanthone, tannin, carotenoid, flavones and alkaloids using standard methods. Results and conclusions: All 12 of the 30 selected recipes (40%) demonstrated antihypertensive activity with the maximum decrease of MABP at 27.17±3.17% that was 2.41-fold of prazosin hydrochloride. Most recipes exhibiting antihypertensive activity contained plants in the families of Zingiberaceae and Piperaceae. The top five antihypertensive recipes showed the presence of glycosides, xanthones and alkaloids. Ten single plants from these recipes were extracted and evaluated for antihypertensive activity. The cassumunar ginger extract exhibited the maximum decrease of MABP at 39.83±3.92%, which was 3.54-times that of prazosin hydrochloride. This study demonstrated the potent antihypertensive activity of Thai medicinal plants and recipes that can be further developed as antihypertensive agents. © 2013 Informa Healthcare USA, Inc.
format Article
author Manosroi A.
Lohcharoenkal W.
Khonsung P.
Manosroi W.
Manosroi J.
spellingShingle Manosroi A.
Lohcharoenkal W.
Khonsung P.
Manosroi W.
Manosroi J.
Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database
author_facet Manosroi A.
Lohcharoenkal W.
Khonsung P.
Manosroi W.
Manosroi J.
author_sort Manosroi A.
title Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database
title_short Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database
title_full Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database
title_fullStr Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database
title_full_unstemmed Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database
title_sort potent antihypertensive activity of thai-lanna medicinal plants and recipes from "manosroi iii" database
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84885614367&partnerID=40&md5=8c1753b1bababa18d550d3be95fa71e2
http://cmuir.cmu.ac.th/handle/6653943832/4199
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