Comparison of maternal serum PlGF and sFlt-1 between pregnancies with and without fetal hemoglobin Bart's disease

Objective: The aim of this study was to compare the levels of maternal serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) between pregnancies with fetal hemoglobin (Hb) Bart's disease and unaffected pregnancies. Methods: Ninety-one pregnancies at risk for fetal...

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Main Authors: Tongprasert F., Srisupundit K., Luewan S., Tongsong T.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84889673577&partnerID=40&md5=a6e71ee0728d9a184d747dc6a2d8844f
http://cmuir.cmu.ac.th/handle/6653943832/4202
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-42022014-08-30T02:35:47Z Comparison of maternal serum PlGF and sFlt-1 between pregnancies with and without fetal hemoglobin Bart's disease Tongprasert F. Srisupundit K. Luewan S. Tongsong T. Objective: The aim of this study was to compare the levels of maternal serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) between pregnancies with fetal hemoglobin (Hb) Bart's disease and unaffected pregnancies. Methods: Ninety-one pregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18-22weeks were recruited into the study. Maternal serum PlGF and sFlt-1 concentrations were measured before cordocentesis. Fetal blood samples were collected for thalassemia diagnosis based on fetal Hb typing using high-performance liquid chromatography. PlGF, sFlt-1, and sFlt-1/PlGF ratio were compared between the fetal Hb Bart's group and the non-Hb Bart's group (normal Hb typing or α-thalassemia-1 carrier). Results: Maternal serum concentration of PlGF was significantly higher in women with fetal Hb Bart's disease (18 cases) than those with unaffected fetuses (71 cases) (P=0.008), whereas the concentration of sFlt-1 was not significantly different (P=0.139). However, the sFlt-1/PlGF ratio was significantly lower in women with fetal Hb Bart's disease than those with unaffected fetuses (P=0.001). Conclusion: Placental growth factor may help differentiate affected from unaffected fetuses among pregnancies at risk, though further studies are needed to confirm its usefulness. In addition, preeclampsia prediction using these markers may be unreliable in pregnancies with placental dysfunction secondary to severe fetal anemia. © 2013 John Wiley & Sons, Ltd. 2014-08-30T02:35:47Z 2014-08-30T02:35:47Z 2013 Article 01973851 10.1002/pd.4246 PRDID http://www.scopus.com/inward/record.url?eid=2-s2.0-84889673577&partnerID=40&md5=a6e71ee0728d9a184d747dc6a2d8844f http://cmuir.cmu.ac.th/handle/6653943832/4202 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objective: The aim of this study was to compare the levels of maternal serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) between pregnancies with fetal hemoglobin (Hb) Bart's disease and unaffected pregnancies. Methods: Ninety-one pregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18-22weeks were recruited into the study. Maternal serum PlGF and sFlt-1 concentrations were measured before cordocentesis. Fetal blood samples were collected for thalassemia diagnosis based on fetal Hb typing using high-performance liquid chromatography. PlGF, sFlt-1, and sFlt-1/PlGF ratio were compared between the fetal Hb Bart's group and the non-Hb Bart's group (normal Hb typing or α-thalassemia-1 carrier). Results: Maternal serum concentration of PlGF was significantly higher in women with fetal Hb Bart's disease (18 cases) than those with unaffected fetuses (71 cases) (P=0.008), whereas the concentration of sFlt-1 was not significantly different (P=0.139). However, the sFlt-1/PlGF ratio was significantly lower in women with fetal Hb Bart's disease than those with unaffected fetuses (P=0.001). Conclusion: Placental growth factor may help differentiate affected from unaffected fetuses among pregnancies at risk, though further studies are needed to confirm its usefulness. In addition, preeclampsia prediction using these markers may be unreliable in pregnancies with placental dysfunction secondary to severe fetal anemia. © 2013 John Wiley & Sons, Ltd.
format Article
author Tongprasert F.
Srisupundit K.
Luewan S.
Tongsong T.
spellingShingle Tongprasert F.
Srisupundit K.
Luewan S.
Tongsong T.
Comparison of maternal serum PlGF and sFlt-1 between pregnancies with and without fetal hemoglobin Bart's disease
author_facet Tongprasert F.
Srisupundit K.
Luewan S.
Tongsong T.
author_sort Tongprasert F.
title Comparison of maternal serum PlGF and sFlt-1 between pregnancies with and without fetal hemoglobin Bart's disease
title_short Comparison of maternal serum PlGF and sFlt-1 between pregnancies with and without fetal hemoglobin Bart's disease
title_full Comparison of maternal serum PlGF and sFlt-1 between pregnancies with and without fetal hemoglobin Bart's disease
title_fullStr Comparison of maternal serum PlGF and sFlt-1 between pregnancies with and without fetal hemoglobin Bart's disease
title_full_unstemmed Comparison of maternal serum PlGF and sFlt-1 between pregnancies with and without fetal hemoglobin Bart's disease
title_sort comparison of maternal serum plgf and sflt-1 between pregnancies with and without fetal hemoglobin bart's disease
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84889673577&partnerID=40&md5=a6e71ee0728d9a184d747dc6a2d8844f
http://cmuir.cmu.ac.th/handle/6653943832/4202
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