Novel genomic island modifies DNA with 7-deazaguanine derivatives

• Main Authors: Thiaville J., Kellner S., Yuan Y., Hutinet G., Thiaville P., Jumpathong W., Mohapatra S., Brochier-Armanet C., Letarov A., Hillebrand R., Malik C., Rizzo C., Dedon P., De Crécy-Lagard V.
• Format: Journal
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961789525&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/42022
• Institution: Chiang Mai University

The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ 0 ) synthesis and DNA metabolism genes, led to the hypothesis that 7-deazaguanine derivatives are inserted in DNA. This was established...