Protective effect of Cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium

© 2016 by the authors. Cadmium nephrotoxicity is a serious environmental health problem as it will eventually end up with end stage renal disease. The pathobiochemical mechanism of this toxic heavy metal is related to oxidative stress. This study investigated whether Cleistocalyx nervosum var. pania...

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Main Authors: Poontawee W., Natakankitkul S., Wongmekiat O.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84962809881&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42102
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-421022017-09-28T04:25:13Z Protective effect of Cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium Poontawee W. Natakankitkul S. Wongmekiat O. © 2016 by the authors. Cadmium nephrotoxicity is a serious environmental health problem as it will eventually end up with end stage renal disease. The pathobiochemical mechanism of this toxic heavy metal is related to oxidative stress. This study investigated whether Cleistocalyx nervosum var. paniala fruit extract (CNFE) could protect the kidney against oxidative injury caused by cadmium. Initial analysis of the extract revealed antioxidant abilities and high levels of polyphenols, particularly catechin. Its potential renal benefits was further explored in rats treated with vehicle, CNFE, cadmium (2 mg/kg), and cadmium plus CNFE (0.5, 1, 2 g/kg) for four weeks. Oxidative renal injury was developed after cadmium exposure as evidenced by blood urea nitrogen and creatinine retention, glomerular filtration reduction, renal structural damage, together with increased nitric oxide and malondialdehyde, but decreased antioxidant thiols, superoxide dismutase, and catalase in renal tissues. Cadmium-induced nephrotoxicity was diminished in rats supplemented with CNFE, particularly at the doses of 1 and 2 g/kg. It is concluded that CNFE is able to protect against the progression of cadmium nephrotoxicity, mostly via its antioxidant power. The results also point towards a promising role for this naturally-occurring antioxidant to combat other human disorders elicited by disruption of redox homeostasis. 2017-09-28T04:25:12Z 2017-09-28T04:25:12Z 2016-02-01 Journal 2-s2.0-84962809881 10.3390/molecules21020133 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84962809881&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42102
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2016 by the authors. Cadmium nephrotoxicity is a serious environmental health problem as it will eventually end up with end stage renal disease. The pathobiochemical mechanism of this toxic heavy metal is related to oxidative stress. This study investigated whether Cleistocalyx nervosum var. paniala fruit extract (CNFE) could protect the kidney against oxidative injury caused by cadmium. Initial analysis of the extract revealed antioxidant abilities and high levels of polyphenols, particularly catechin. Its potential renal benefits was further explored in rats treated with vehicle, CNFE, cadmium (2 mg/kg), and cadmium plus CNFE (0.5, 1, 2 g/kg) for four weeks. Oxidative renal injury was developed after cadmium exposure as evidenced by blood urea nitrogen and creatinine retention, glomerular filtration reduction, renal structural damage, together with increased nitric oxide and malondialdehyde, but decreased antioxidant thiols, superoxide dismutase, and catalase in renal tissues. Cadmium-induced nephrotoxicity was diminished in rats supplemented with CNFE, particularly at the doses of 1 and 2 g/kg. It is concluded that CNFE is able to protect against the progression of cadmium nephrotoxicity, mostly via its antioxidant power. The results also point towards a promising role for this naturally-occurring antioxidant to combat other human disorders elicited by disruption of redox homeostasis.
format Journal
author Poontawee W.
Natakankitkul S.
Wongmekiat O.
spellingShingle Poontawee W.
Natakankitkul S.
Wongmekiat O.
Protective effect of Cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium
author_facet Poontawee W.
Natakankitkul S.
Wongmekiat O.
author_sort Poontawee W.
title Protective effect of Cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium
title_short Protective effect of Cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium
title_full Protective effect of Cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium
title_fullStr Protective effect of Cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium
title_full_unstemmed Protective effect of Cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium
title_sort protective effect of cleistocalyx nervosum var. paniala fruit extract against oxidative renal damage caused by cadmium
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84962809881&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42102
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