Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos

Poloxamer micelles promise safety and efficacy for many water insoluble drugs. Chrysin has been reported to have anticancer, anti-inflammatory, antioxidant, and anti-aromatase activities but its water insoluble properties limit its pharmaceutical application. In the present study, chrysin loaded pol...

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Main Authors: Sassa-deepaeng T., Pikulkaew S., Okonogi S.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008749119&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42293
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-422932017-09-28T04:26:19Z Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos Sassa-deepaeng T. Pikulkaew S. Okonogi S. Pikulkaew S. Okonogi S. Poloxamer micelles promise safety and efficacy for many water insoluble drugs. Chrysin has been reported to have anticancer, anti-inflammatory, antioxidant, and anti-aromatase activities but its water insoluble properties limit its pharmaceutical application. In the present study, chrysin loaded poloxamer micelles were developed. Two types of poloxamers, Pluronic F-68 and Pluronic F-127 were compared. It was found that chrysin loaded Pluronic F-68 micelles (CS-P68) and chrysin loaded Pluronic F-127 micelles (CS-P127) obviously increase the aqueous solubility of chrysin. The results also indicated that the type of polymer and ratio of drug to polymer affected size and desirable characteristics of the micelles. The micelle system of CS-P68 and CS-P127 formed at drug to polymer ratios of 1:4 and 1:2, respectively, was found to be the most suitable monodispersed system with a nanosize-range diameter. The in vivo study in zebrafish eggs indicates that the toxicity of CS-P68 and CS-P127 is a dose response. CS-P68 and CS-P127 at a drug dose of 10 ng/mL or less is safe for zebrafish embryo growth. The results of this study indicate enhanced water solubility of chrysin. Chrysin loaded poloxamer micelles are promising for further use in in vivo studies in mammalian animals and humans. © 2016, International Research and Cooperation Association for Bio & Socio-Sciences Advancement. All rights reserved. 2017-09-28T04:26:19Z 2017-09-28T04:26:19Z 2016-01-01 Journal 18817831 2-s2.0-85008749119 10.5582/ddt.2016.01039 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008749119&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42293
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Poloxamer micelles promise safety and efficacy for many water insoluble drugs. Chrysin has been reported to have anticancer, anti-inflammatory, antioxidant, and anti-aromatase activities but its water insoluble properties limit its pharmaceutical application. In the present study, chrysin loaded poloxamer micelles were developed. Two types of poloxamers, Pluronic F-68 and Pluronic F-127 were compared. It was found that chrysin loaded Pluronic F-68 micelles (CS-P68) and chrysin loaded Pluronic F-127 micelles (CS-P127) obviously increase the aqueous solubility of chrysin. The results also indicated that the type of polymer and ratio of drug to polymer affected size and desirable characteristics of the micelles. The micelle system of CS-P68 and CS-P127 formed at drug to polymer ratios of 1:4 and 1:2, respectively, was found to be the most suitable monodispersed system with a nanosize-range diameter. The in vivo study in zebrafish eggs indicates that the toxicity of CS-P68 and CS-P127 is a dose response. CS-P68 and CS-P127 at a drug dose of 10 ng/mL or less is safe for zebrafish embryo growth. The results of this study indicate enhanced water solubility of chrysin. Chrysin loaded poloxamer micelles are promising for further use in in vivo studies in mammalian animals and humans. © 2016, International Research and Cooperation Association for Bio & Socio-Sciences Advancement. All rights reserved.
format Journal
author Sassa-deepaeng T.
Pikulkaew S.
Okonogi S.
Pikulkaew S.
Okonogi S.
spellingShingle Sassa-deepaeng T.
Pikulkaew S.
Okonogi S.
Pikulkaew S.
Okonogi S.
Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos
author_facet Sassa-deepaeng T.
Pikulkaew S.
Okonogi S.
Pikulkaew S.
Okonogi S.
author_sort Sassa-deepaeng T.
title Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos
title_short Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos
title_full Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos
title_fullStr Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos
title_full_unstemmed Development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos
title_sort development of chrysin loaded poloxamer micelles and toxicity evaluation in fish embryos
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008749119&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42293
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