Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study

© 2016 Patcharanee Tawasri et al. The objective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on pharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following or...

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Main Authors: Tawasri P., Ampasavate C., Tharatha S., Chiranthanut N., Teekachunhatean S.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991384811&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42430
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spelling th-cmuir.6653943832-424302017-09-28T04:27:05Z Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study Tawasri P. Ampasavate C. Tharatha S. Chiranthanut N. Teekachunhatean S. © 2016 Patcharanee Tawasri et al. The objective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on pharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following oral administration of water extract of fruiting bodies of Ling Zhi in 12 healthy male subjects. Each subject was randomized to receive either one of the two regimens: (1) a single dose of 3,000 mg of the Ling Zhi preparation or (2) a single dose of 3,000 mg of the Ling Zhi preparation in combination with 2,500 mg of ascorbic acid. After a washout period of at least two weeks, subjects were switched to receive the alternate regimen. Blood samples were collected in each phase immediately before dosing and at specific time points for 8 hours after dosing. Plasma ganoderic acid A concentrations were quantified using liquid chromatography-mass spectrometry (LC-MS). The pharmacokinetic parameters analyzed were maximal plasma concentration (C m a x), time to reach peak concentration (T m a x), area under the plasma concentration-time curve (A U C), and half-life (t 1 / 2). An oral coadministration of ascorbic acid with Ling Zhi preparation did not significantly alter the pharmacokinetic parameters of ganoderic acid A in healthy male subjects. 2017-09-28T04:27:05Z 2017-09-28T04:27:05Z 2016-01-01 Journal 23146133 2-s2.0-84991384811 10.1155/2016/2819862 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991384811&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42430
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2016 Patcharanee Tawasri et al. The objective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on pharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following oral administration of water extract of fruiting bodies of Ling Zhi in 12 healthy male subjects. Each subject was randomized to receive either one of the two regimens: (1) a single dose of 3,000 mg of the Ling Zhi preparation or (2) a single dose of 3,000 mg of the Ling Zhi preparation in combination with 2,500 mg of ascorbic acid. After a washout period of at least two weeks, subjects were switched to receive the alternate regimen. Blood samples were collected in each phase immediately before dosing and at specific time points for 8 hours after dosing. Plasma ganoderic acid A concentrations were quantified using liquid chromatography-mass spectrometry (LC-MS). The pharmacokinetic parameters analyzed were maximal plasma concentration (C m a x), time to reach peak concentration (T m a x), area under the plasma concentration-time curve (A U C), and half-life (t 1 / 2). An oral coadministration of ascorbic acid with Ling Zhi preparation did not significantly alter the pharmacokinetic parameters of ganoderic acid A in healthy male subjects.
format Journal
author Tawasri P.
Ampasavate C.
Tharatha S.
Chiranthanut N.
Teekachunhatean S.
spellingShingle Tawasri P.
Ampasavate C.
Tharatha S.
Chiranthanut N.
Teekachunhatean S.
Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study
author_facet Tawasri P.
Ampasavate C.
Tharatha S.
Chiranthanut N.
Teekachunhatean S.
author_sort Tawasri P.
title Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study
title_short Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study
title_full Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study
title_fullStr Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study
title_full_unstemmed Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study
title_sort effect of oral coadministration of ascorbic acid with ling zhi preparation on pharmacokinetics of ganoderic acid a in healthy male subjects: a randomized crossover study
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991384811&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42430
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