The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction

• Main Authors: Lekawanvijit S., Kumfu S., Wang B.H., Manabe M., Nishijima F., Kelly D.J., Krum H., Kompa A.R.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84892549194&partnerID=40&md5=05e423bec1ee1d2de6b116331852f599; http://cmuir.cmu.ac.th/handle/6653943832/4268
• Institution: Chiang Mai University

An accelerated progressive decline in renal function is a frequent accompaniment of myocardial infarction (MI). Indoxyl sulfate (IS), a uremic toxin that accumulates from the early stages of chronic kidney disease (CKD), is contributory to both renal and cardiac fibrosis. IS levels can be reduced by...