Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study

Background: Several botanically derived agents are available for the treatment of male-pattern baldness. Objective: The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5a-reductase and 5% minoxidil in the treatment of andr...

Full description

Saved in:
Bibliographic Details
Main Authors: Pumthong G., Asawanonda P., Varothai S., Jariyasethavong V., Triwongwaranat D., Suthipinittharm P., Ingkaninan K., Leelapornpisit P., Waranuch N.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866295887&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42764
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-42764
record_format dspace
spelling th-cmuir.6653943832-427642017-09-28T06:38:45Z Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study Pumthong G. Asawanonda P. Varothai S. Jariyasethavong V. Triwongwaranat D. Suthipinittharm P. Ingkaninan K. Leelapornpisit P. Waranuch N. Background: Several botanically derived agents are available for the treatment of male-pattern baldness. Objective: The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5a-reductase and 5% minoxidil in the treatment of androgenetic alopecia. Methods: Eighty-seven men with androgenetic alopecia (AGA) were randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months. Efficacy was assessed by target area hair count, global photographic review as well as patients' subjective assessments of hair regrowth and hair shedding. Results: There were statistically significant improvements in global photographic review (p < 0.001), subjects' overall assessments of hair regrowth (p = 0.008), and hair shedding (p = 0.004) when the combination formulation was compared with placebo. Similarly, treatment with 5% minoxidil and 5% C. aeruginosa extract also led to some degrees of hair regrowth. There were no serious adverse events during and after the study. Conclusion: In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth. © 2012 Informa Healthcare USA on behalf of Informa UK Ltd. 2017-09-28T06:38:45Z 2017-09-28T06:38:45Z 2012-10-01 Journal 09546634 2-s2.0-84866295887 10.3109/09546634.2011.568470 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866295887&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42764
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Background: Several botanically derived agents are available for the treatment of male-pattern baldness. Objective: The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5a-reductase and 5% minoxidil in the treatment of androgenetic alopecia. Methods: Eighty-seven men with androgenetic alopecia (AGA) were randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months. Efficacy was assessed by target area hair count, global photographic review as well as patients' subjective assessments of hair regrowth and hair shedding. Results: There were statistically significant improvements in global photographic review (p < 0.001), subjects' overall assessments of hair regrowth (p = 0.008), and hair shedding (p = 0.004) when the combination formulation was compared with placebo. Similarly, treatment with 5% minoxidil and 5% C. aeruginosa extract also led to some degrees of hair regrowth. There were no serious adverse events during and after the study. Conclusion: In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth. © 2012 Informa Healthcare USA on behalf of Informa UK Ltd.
format Journal
author Pumthong G.
Asawanonda P.
Varothai S.
Jariyasethavong V.
Triwongwaranat D.
Suthipinittharm P.
Ingkaninan K.
Leelapornpisit P.
Waranuch N.
spellingShingle Pumthong G.
Asawanonda P.
Varothai S.
Jariyasethavong V.
Triwongwaranat D.
Suthipinittharm P.
Ingkaninan K.
Leelapornpisit P.
Waranuch N.
Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
author_facet Pumthong G.
Asawanonda P.
Varothai S.
Jariyasethavong V.
Triwongwaranat D.
Suthipinittharm P.
Ingkaninan K.
Leelapornpisit P.
Waranuch N.
author_sort Pumthong G.
title Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
title_short Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
title_full Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
title_fullStr Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
title_full_unstemmed Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
title_sort curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866295887&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42764
_version_ 1681422251244650496