Hb A2/E levels found in co-inheritance with the α-thalassemia-1- SEA/ type deletion and either Hb e or β-thalassemia
The α-thalassemia-1 (α-thal-1) Southeast Asian ( SEA ) type deletion, β-thalassemia (β-thal) and Hb E [β26(B8)Glu→Lys, GAG > AAG] are the most common genetic disorders in Southeast Asian populations. Mean corpuscular volume (MCV) < 80.0 fL with normal hemoglobin (Hb) is used for screening α-...
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th-cmuir.6653943832-428012017-09-28T06:39:29Z Hb A2/E levels found in co-inheritance with the α-thalassemia-1- SEA/ type deletion and either Hb e or β-thalassemia Pornprasert S. Treesuwan K. Punyamung M. Kongthai K. The α-thalassemia-1 (α-thal-1) Southeast Asian ( SEA ) type deletion, β-thalassemia (β-thal) and Hb E [β26(B8)Glu→Lys, GAG > AAG] are the most common genetic disorders in Southeast Asian populations. Mean corpuscular volume (MCV) < 80.0 fL with normal hemoglobin (Hb) is used for screening α- and β-thal, and a Hb E level of less than 25.0 is used for predicting α-thal-1 in Hb E trait. Thus, levels of Hb, MCV and Hb A2/E were reviewed and compared between the SEA type deletion co-inherited with β-thal trait (n 61), with Hb E trait (n 102) or homozygous Hb E (n 13) and β-thal trait (n 636), Hb E trait (n 544) or homozygous Hb E (n 83), respectively. When comparing the values of all three analyzed hematological parameters, only the SEA /β E values were shown to be significantly lower than those of Hb E trait. Furthermore, at a cut-off value of Hb A2/E of 21.54, 95.0 of the SEA /β E had Hb A2/E levels lower than this cut-off value, while 94.0 of Hb E trait had Hb A2/E at higher levels. Accordingly, the Hb A2/E level at 21.54 is the best indicator for predicting co-inheritance of the α-thal-1 SEA / deletion and Hb E trait. © 2012 Informa Healthcare USA, Inc. 2017-09-28T06:39:29Z 2017-09-28T06:39:29Z 2012-08-01 Journal 03630269 2-s2.0-84862863861 10.3109/03630269.2012.679375 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84862863861&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42801 |
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The α-thalassemia-1 (α-thal-1) Southeast Asian ( SEA ) type deletion, β-thalassemia (β-thal) and Hb E [β26(B8)Glu→Lys, GAG > AAG] are the most common genetic disorders in Southeast Asian populations. Mean corpuscular volume (MCV) < 80.0 fL with normal hemoglobin (Hb) is used for screening α- and β-thal, and a Hb E level of less than 25.0 is used for predicting α-thal-1 in Hb E trait. Thus, levels of Hb, MCV and Hb A2/E were reviewed and compared between the SEA type deletion co-inherited with β-thal trait (n 61), with Hb E trait (n 102) or homozygous Hb E (n 13) and β-thal trait (n 636), Hb E trait (n 544) or homozygous Hb E (n 83), respectively. When comparing the values of all three analyzed hematological parameters, only the SEA /β E values were shown to be significantly lower than those of Hb E trait. Furthermore, at a cut-off value of Hb A2/E of 21.54, 95.0 of the SEA /β E had Hb A2/E levels lower than this cut-off value, while 94.0 of Hb E trait had Hb A2/E at higher levels. Accordingly, the Hb A2/E level at 21.54 is the best indicator for predicting co-inheritance of the α-thal-1 SEA / deletion and Hb E trait. © 2012 Informa Healthcare USA, Inc. |
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Pornprasert S. Treesuwan K. Punyamung M. Kongthai K. |
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Pornprasert S. Treesuwan K. Punyamung M. Kongthai K. Hb A2/E levels found in co-inheritance with the α-thalassemia-1- SEA/ type deletion and either Hb e or β-thalassemia |
author_facet |
Pornprasert S. Treesuwan K. Punyamung M. Kongthai K. |
author_sort |
Pornprasert S. |
title |
Hb A2/E levels found in co-inheritance with the α-thalassemia-1- SEA/ type deletion and either Hb e or β-thalassemia |
title_short |
Hb A2/E levels found in co-inheritance with the α-thalassemia-1- SEA/ type deletion and either Hb e or β-thalassemia |
title_full |
Hb A2/E levels found in co-inheritance with the α-thalassemia-1- SEA/ type deletion and either Hb e or β-thalassemia |
title_fullStr |
Hb A2/E levels found in co-inheritance with the α-thalassemia-1- SEA/ type deletion and either Hb e or β-thalassemia |
title_full_unstemmed |
Hb A2/E levels found in co-inheritance with the α-thalassemia-1- SEA/ type deletion and either Hb e or β-thalassemia |
title_sort |
hb a2/e levels found in co-inheritance with the α-thalassemia-1- sea/ type deletion and either hb e or β-thalassemia |
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2017 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84862863861&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42801 |
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