Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings

• Main Authors: Campbell T., Smeaton L., Kumarasamy N., Flanigan T., Klingman K., Firnhaber C., Grinsztejn B., Hosseinipour M., Kumwenda J., Lalloo U., Riviere C., Sanchez J., Melo M., Supparatpinyo K., Tripathy S., Martinez A., Nair A., Walawander A., Moran L., Chen Y., Snowden W., Rooney J., Uy J., Schooley R., de Gruttola V., Hakim J., Swann E., Barnett R., Brizz B., Delph Y., Gettinger N., Mitsuyasu R., Eshleman S., Safren S., Fiscus S., Andrade A., Haas D., Amod F., Berthaud V., Bollinger R., Bryson Y., Celentano D., Chilongozi D., Cohen M., Collier A., Currier J., Cu-Uvin S., Eron J., Flexner C., Gallant J., Gulick R., Hammer S., Hoffman I., Kazembe P., Kumwenda N., Lama J., Lawrence J., Maponga C., Martinson F., Mayer K., Nielsen K., Pendame R., Ramratnam B., Sanne I., Severe P., Sirisanthana T., Solomon S., Tabet S., Taha T., van der Horst C., Wanke C., Gormley J., Marcus C., Putnam B., Ntshele S., Loeliger E., Pappa K., Webb N., Shugarts D., Winters M., Descallar R., Steele J., Wulfsohn M., Said F., Martin J., Bischofberger N., Cheng A., Jaffe H., Sharma J., Poongulali S., Cardoso S., Faria D., Berendes S., Burke K., Mngqibisa R., Kanyama C., Kayoyo V., Samaneka W., Chisada A.
• Format: Journal
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865566725&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/42806
• Institution: Chiang Mai University

Background:Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-daily compared to twice-daily dosing in diverse area...