Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand

Background.Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear how COC use impacts risk of cervical carcinogenesis.Methods.We estimated the risk of new human papillomavirus (HPV) DNA detection and persistence among 113...

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Main Authors: Marks M., Gravitt P., Gupta S., Liaw K., Tadesse A., Kim E., Phongnarisorn C., Wootipoom V., Yuenyao P., Vipupinyo C., Sriplienchan S., Celentano D.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80054732065&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42971
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-429712017-09-28T06:44:44Z Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand Marks M. Gravitt P. Gupta S. Liaw K. Tadesse A. Kim E. Phongnarisorn C. Wootipoom V. Yuenyao P. Vipupinyo C. Sriplienchan S. Celentano D. Background.Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear how COC use impacts risk of cervical carcinogenesis.Methods.We estimated the risk of new human papillomavirus (HPV) DNA detection and persistence among 1135 human immunodeficiency virus (HIV)-negative women aged 20-37 years from Thailand who were followed for 18 months at 6-month intervals. Type-specific HPV DNA, demographic information, hormonal contraceptive use, sexual behavior, genital tract coinfection, and Papanicolaou test results were assessed at baseline and each follow-up.Results.Women who reported current COC use during follow-up were less likely to clear HPV infection compared with nonusers, independent of sexual behavior, and Papanicolaou test diagnosis (AHR: 0.67 [95% CI:. 49-.93]). Similar associations were not observed among women reporting current use of depomedroxyprogesterone acetate (DMPA). Neither COC nor DMPA use was significantly associated with new HPV DNA detection.Conclusions.These data do not support the hypothesis that contraceptive use is associated with cervical cancer risk via increased risk of HPV acquisition. The increased risk of HPV persistence observed among current COC users suggests a possible influence of female sex hormones on host response to HPV infection. © The Author 2011. 2017-09-28T06:44:44Z 2017-09-28T06:44:44Z 2011-11-15 Journal 00221899 2-s2.0-80054732065 10.1093/infdis/jir560 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80054732065&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42971
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Background.Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear how COC use impacts risk of cervical carcinogenesis.Methods.We estimated the risk of new human papillomavirus (HPV) DNA detection and persistence among 1135 human immunodeficiency virus (HIV)-negative women aged 20-37 years from Thailand who were followed for 18 months at 6-month intervals. Type-specific HPV DNA, demographic information, hormonal contraceptive use, sexual behavior, genital tract coinfection, and Papanicolaou test results were assessed at baseline and each follow-up.Results.Women who reported current COC use during follow-up were less likely to clear HPV infection compared with nonusers, independent of sexual behavior, and Papanicolaou test diagnosis (AHR: 0.67 [95% CI:. 49-.93]). Similar associations were not observed among women reporting current use of depomedroxyprogesterone acetate (DMPA). Neither COC nor DMPA use was significantly associated with new HPV DNA detection.Conclusions.These data do not support the hypothesis that contraceptive use is associated with cervical cancer risk via increased risk of HPV acquisition. The increased risk of HPV persistence observed among current COC users suggests a possible influence of female sex hormones on host response to HPV infection. © The Author 2011.
format Journal
author Marks M.
Gravitt P.
Gupta S.
Liaw K.
Tadesse A.
Kim E.
Phongnarisorn C.
Wootipoom V.
Yuenyao P.
Vipupinyo C.
Sriplienchan S.
Celentano D.
spellingShingle Marks M.
Gravitt P.
Gupta S.
Liaw K.
Tadesse A.
Kim E.
Phongnarisorn C.
Wootipoom V.
Yuenyao P.
Vipupinyo C.
Sriplienchan S.
Celentano D.
Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand
author_facet Marks M.
Gravitt P.
Gupta S.
Liaw K.
Tadesse A.
Kim E.
Phongnarisorn C.
Wootipoom V.
Yuenyao P.
Vipupinyo C.
Sriplienchan S.
Celentano D.
author_sort Marks M.
title Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand
title_short Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand
title_full Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand
title_fullStr Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand
title_full_unstemmed Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand
title_sort combined oral contraceptive use increases hpv persistence but not new hpv detection in a cohort of women from thailand
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80054732065&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42971
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