HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)

Background: Project Accept is a community randomized, controlled trial to evaluate the efficacy of community mobilization, mobile testing, same-day results, and post-test support for the prevention of HIV infection in Thailand, Tanzania, Zimbabwe, and South Africa. We evaluated the accuracy of in-co...

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Main Authors: Piwowar-Manning E., Fiamma A., Laeyendecker O., Kulich M., Donnell D., Szekeres G., Robins-Morris L., Mullis C., Vallari A., Hackett J., Mastro T., Gray G., Richter L., Alexandre M., Chariyalertsak S., Chingono A., Sweat M., Coates T., Eshleman S.
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Published: 2017
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/42989
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spelling th-cmuir.6653943832-429892017-09-28T06:45:23Z HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043) Piwowar-Manning E. Fiamma A. Laeyendecker O. Kulich M. Donnell D. Szekeres G. Robins-Morris L. Mullis C. Vallari A. Hackett J. Mastro T. Gray G. Richter L. Alexandre M. Chariyalertsak S. Chingono A. Sweat M. Coates T. Eshleman S. Background: Project Accept is a community randomized, controlled trial to evaluate the efficacy of community mobilization, mobile testing, same-day results, and post-test support for the prevention of HIV infection in Thailand, Tanzania, Zimbabwe, and South Africa. We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study.Methods: Two HIV rapid tests were performed in parallel in local laboratories. If the first two rapid tests were discordant (one reactive, one non-reactive), a third HIV rapid test or enzyme immunoassay was performed. Samples were designated HIV NEG if the first two tests were non-reactive, HIV DISC if the first two tests were discordant, and HIV POS if the first two tests were reactive. Samples were re-analyzed in the United States using a panel of laboratory tests.Results: HIV infection status was correctly determined based on-in country testing for 2,236 (99.5%) of 2,247 participants [7 (0.37%) of 1,907 HIV NEG samples were HIV-positive; 2 (0.63%) of 317 HIV POS samples were HIV-negative; 2 (8.3%) of 24 HIV DISC samples were incorrectly identified as HIV-positive based on the in-country tie-breaker test]. HIV prevalence was: Thailand: 0.6%, Tanzania: 5.0%, Zimbabwe 14.7%, Soweto South Africa: 19.4%, Vulindlela, South Africa: 24.4%, (overall prevalence: 14.4%).Conclusions: In-country testing based on two HIV rapid tests correctly identified the HIV infection status for 99.5% of study participants; most participants with discordant HIV rapid tests were not infected. HIV prevalence varied considerably across the study sites (range: 0.6% to 24.4%).Trial Registration: ClinicalTrials.gov registry number NCT00203749. © 2011 Piwowar-Manning et al; licensee BioMed Central Ltd. 2017-09-28T06:45:23Z 2017-09-28T06:45:23Z 2011-09-24 Journal 2-s2.0-80053173912 10.1186/1471-2334-11-251 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053173912&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42989
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Background: Project Accept is a community randomized, controlled trial to evaluate the efficacy of community mobilization, mobile testing, same-day results, and post-test support for the prevention of HIV infection in Thailand, Tanzania, Zimbabwe, and South Africa. We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study.Methods: Two HIV rapid tests were performed in parallel in local laboratories. If the first two rapid tests were discordant (one reactive, one non-reactive), a third HIV rapid test or enzyme immunoassay was performed. Samples were designated HIV NEG if the first two tests were non-reactive, HIV DISC if the first two tests were discordant, and HIV POS if the first two tests were reactive. Samples were re-analyzed in the United States using a panel of laboratory tests.Results: HIV infection status was correctly determined based on-in country testing for 2,236 (99.5%) of 2,247 participants [7 (0.37%) of 1,907 HIV NEG samples were HIV-positive; 2 (0.63%) of 317 HIV POS samples were HIV-negative; 2 (8.3%) of 24 HIV DISC samples were incorrectly identified as HIV-positive based on the in-country tie-breaker test]. HIV prevalence was: Thailand: 0.6%, Tanzania: 5.0%, Zimbabwe 14.7%, Soweto South Africa: 19.4%, Vulindlela, South Africa: 24.4%, (overall prevalence: 14.4%).Conclusions: In-country testing based on two HIV rapid tests correctly identified the HIV infection status for 99.5% of study participants; most participants with discordant HIV rapid tests were not infected. HIV prevalence varied considerably across the study sites (range: 0.6% to 24.4%).Trial Registration: ClinicalTrials.gov registry number NCT00203749. © 2011 Piwowar-Manning et al; licensee BioMed Central Ltd.
format Journal
author Piwowar-Manning E.
Fiamma A.
Laeyendecker O.
Kulich M.
Donnell D.
Szekeres G.
Robins-Morris L.
Mullis C.
Vallari A.
Hackett J.
Mastro T.
Gray G.
Richter L.
Alexandre M.
Chariyalertsak S.
Chingono A.
Sweat M.
Coates T.
Eshleman S.
spellingShingle Piwowar-Manning E.
Fiamma A.
Laeyendecker O.
Kulich M.
Donnell D.
Szekeres G.
Robins-Morris L.
Mullis C.
Vallari A.
Hackett J.
Mastro T.
Gray G.
Richter L.
Alexandre M.
Chariyalertsak S.
Chingono A.
Sweat M.
Coates T.
Eshleman S.
HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
author_facet Piwowar-Manning E.
Fiamma A.
Laeyendecker O.
Kulich M.
Donnell D.
Szekeres G.
Robins-Morris L.
Mullis C.
Vallari A.
Hackett J.
Mastro T.
Gray G.
Richter L.
Alexandre M.
Chariyalertsak S.
Chingono A.
Sweat M.
Coates T.
Eshleman S.
author_sort Piwowar-Manning E.
title HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_short HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_full HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_fullStr HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_full_unstemmed HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_sort hiv surveillance in a large, community-based study: results from the pilot study of project accept (hiv prevention trials network 043)
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053173912&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/42989
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