Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models

• Main Authors: Liu Y., Tuve S., Persson J., Beyer I., Yumul R., Li Z., Tragoolpua K., Hellström K., Roffler S., Lieber A.
• Format: Journal
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79956110698&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/43055
• Institution: Chiang Mai University

Tumor-associated antigens (TAAs) include overexpressed self-antigens (for example, Her2/neu) and tumor virus antigens (for example, HPV-16 E6/E7). Although in cancer patients, TAA-specific CD4+ and CD8+ cells are often present, they are not able to control tumor growth. In recent studies, it became...