Recent developments in the genetic factors underlying congenital diaphragmatic hernia
Congenital diaphragmatic hernia (CDH) is a birth defect affecting around 1 in 3,000 births and is associated with high mortality and morbidity. It has become increasingly apparent that genetic factors underlie many forms of CDH. We review the recent developments in the area of the genetics of CDH, i...
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th-cmuir.6653943832-431052017-09-28T06:48:06Z Recent developments in the genetic factors underlying congenital diaphragmatic hernia Brady P. Srisupundit K. Devriendt K. Fryns J. Deprest J. Vermeesch J. Congenital diaphragmatic hernia (CDH) is a birth defect affecting around 1 in 3,000 births and is associated with high mortality and morbidity. It has become increasingly apparent that genetic factors underlie many forms of CDH. We review the recent developments in the area of the genetics of CDH, including potential candidate genes supported by evidence from animal models. We also discuss the possible role in the pathogenesis of CDH of defective retinoid signalling and abnormal mesenchymal cell function. Copyright © 2010 S. Karger AG, Basel. 2017-09-28T06:48:06Z 2017-09-28T06:48:06Z 2011-02-01 Journal 10153837 2-s2.0-79951800368 10.1159/000322422 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951800368&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43105 |
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Congenital diaphragmatic hernia (CDH) is a birth defect affecting around 1 in 3,000 births and is associated with high mortality and morbidity. It has become increasingly apparent that genetic factors underlie many forms of CDH. We review the recent developments in the area of the genetics of CDH, including potential candidate genes supported by evidence from animal models. We also discuss the possible role in the pathogenesis of CDH of defective retinoid signalling and abnormal mesenchymal cell function. Copyright © 2010 S. Karger AG, Basel. |
| format |
Journal |
| author |
Brady P. Srisupundit K. Devriendt K. Fryns J. Deprest J. Vermeesch J. |
| spellingShingle |
Brady P. Srisupundit K. Devriendt K. Fryns J. Deprest J. Vermeesch J. Recent developments in the genetic factors underlying congenital diaphragmatic hernia |
| author_facet |
Brady P. Srisupundit K. Devriendt K. Fryns J. Deprest J. Vermeesch J. |
| author_sort |
Brady P. |
| title |
Recent developments in the genetic factors underlying congenital diaphragmatic hernia |
| title_short |
Recent developments in the genetic factors underlying congenital diaphragmatic hernia |
| title_full |
Recent developments in the genetic factors underlying congenital diaphragmatic hernia |
| title_fullStr |
Recent developments in the genetic factors underlying congenital diaphragmatic hernia |
| title_full_unstemmed |
Recent developments in the genetic factors underlying congenital diaphragmatic hernia |
| title_sort |
recent developments in the genetic factors underlying congenital diaphragmatic hernia |
| publishDate |
2017 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951800368&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43105 |
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1681422315631411200 |