Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans
A new stemofoline alkaloid, (2'S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known compounds stemofoline (1), (2'S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J (6), and stilbostemin F (7) have been isolated from the root extracts...
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th-cmuir.6653943832-431112017-09-28T06:48:13Z Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans Sastraruji T. Chaiyong S. Jatisatienr A. Pyne S. Ung A. Lie W. A new stemofoline alkaloid, (2'S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known compounds stemofoline (1), (2'S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J (6), and stilbostemin F (7) have been isolated from the root extracts of Stemona aphylla. The structures and relative configurations of these new compounds have been determined by spectroscopic data interpretation and from semisynthetic studies. These natural and semisynthetic alkaloids were tested for acetylcholinesterase inhibitory activities and were found to be 10-20 times less active than 1',2'-didehydrostemofoline itself. Stemofurans 4, 6, 8, 11, and 13 were tested for their antibacterial and antifungal activities. Three of these showed antibacterial activities against MRSA with MIC values of 15.6 μg/mL. © 2011 American Chemical Society and American Society of Pharmacognosy. 2017-09-28T06:48:13Z 2017-09-28T06:48:13Z 2011-01-28 Journal 01633864 2-s2.0-79951545662 10.1021/np100668s https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951545662&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43111 |
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A new stemofoline alkaloid, (2'S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known compounds stemofoline (1), (2'S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J (6), and stilbostemin F (7) have been isolated from the root extracts of Stemona aphylla. The structures and relative configurations of these new compounds have been determined by spectroscopic data interpretation and from semisynthetic studies. These natural and semisynthetic alkaloids were tested for acetylcholinesterase inhibitory activities and were found to be 10-20 times less active than 1',2'-didehydrostemofoline itself. Stemofurans 4, 6, 8, 11, and 13 were tested for their antibacterial and antifungal activities. Three of these showed antibacterial activities against MRSA with MIC values of 15.6 μg/mL. © 2011 American Chemical Society and American Society of Pharmacognosy. |
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Sastraruji T. Chaiyong S. Jatisatienr A. Pyne S. Ung A. Lie W. |
spellingShingle |
Sastraruji T. Chaiyong S. Jatisatienr A. Pyne S. Ung A. Lie W. Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans |
author_facet |
Sastraruji T. Chaiyong S. Jatisatienr A. Pyne S. Ung A. Lie W. |
author_sort |
Sastraruji T. |
title |
Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans |
title_short |
Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans |
title_full |
Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans |
title_fullStr |
Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans |
title_full_unstemmed |
Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans |
title_sort |
phytochemical studies on stemona aphylla: isolation of a new stemofoline alkaloid and six new stemofurans |
publishDate |
2017 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951545662&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43111 |
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