Mortality among injection drug users in northern thailand: A prospective cohort study

Objectives: To measure mortality rates and assess predictors of all-cause mortality in a cohort of Thai injection drug users (IDUs) who were enrolled and followed up from 2004 through 2006. Methods: In this prospective cohort study, we enrolled 314 community-dwelling IDUs (95% being men; 42% of ethn...

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Main Authors: Quan V., Aramrattana A., Vongchak T., Latkin C., Donnell D., Liu T., Wiboonnatakul K., Celentano D.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79551618877&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43181
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-431812017-09-28T06:51:41Z Mortality among injection drug users in northern thailand: A prospective cohort study Quan V. Aramrattana A. Vongchak T. Latkin C. Donnell D. Liu T. Wiboonnatakul K. Celentano D. Objectives: To measure mortality rates and assess predictors of all-cause mortality in a cohort of Thai injection drug users (IDUs) who were enrolled and followed up from 2004 through 2006. Methods: In this prospective cohort study, we enrolled 314 community-dwelling IDUs (95% being men; 42% of ethnic minority; median age, 29 years [range, 18-69 years]) and followed up them at 6-month intervals. Mortality rates were calculated based on personyears of follow-up. Marginal Cox proportional hazards models for clustered data were constructed to determine the factors associated with all-cause mortality. Findings: During 445.7 person-years of follow-up, 17 of 314 (5.4%) IDUs died. The all-cause mortality rate was 3.8 per 100 person-years (95% confidence interval [CI] = 2.2-6.1). The standardized mortality ratio was 5.8 (95% CI = 3.5-9.1). The mortality rate among HIV-positive IDUs was 13.4 per 100 person-years (95% CI = 5.4 -27.6). In a marginal Cox proportional-hazards model for clustered data, the excess mortality was associated with HIV-positivity (hazard ratio [HR] = 7.0, 95% CI = 2.8 -17.6), benzodiazepine use (HR = 3.1, 95% CI = 1.1-9.4), and excessive alcohol consumption at enrollment (HR = 3.5, 95% CI = 1.3-9.1). Conclusions: The all-cause mortality among the drug injectors is high. The increased mortality was associated with HIV infection, benzodiazepine use, and excessive alcohol consumption. © 2010 American Society of Addiction Medicine. 2017-09-28T06:51:41Z 2017-09-28T06:51:41Z 2010-12-01 Journal 19320620 2-s2.0-79551618877 10.1097/ADM.0b013e3181c78bf4 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79551618877&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43181
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Objectives: To measure mortality rates and assess predictors of all-cause mortality in a cohort of Thai injection drug users (IDUs) who were enrolled and followed up from 2004 through 2006. Methods: In this prospective cohort study, we enrolled 314 community-dwelling IDUs (95% being men; 42% of ethnic minority; median age, 29 years [range, 18-69 years]) and followed up them at 6-month intervals. Mortality rates were calculated based on personyears of follow-up. Marginal Cox proportional hazards models for clustered data were constructed to determine the factors associated with all-cause mortality. Findings: During 445.7 person-years of follow-up, 17 of 314 (5.4%) IDUs died. The all-cause mortality rate was 3.8 per 100 person-years (95% confidence interval [CI] = 2.2-6.1). The standardized mortality ratio was 5.8 (95% CI = 3.5-9.1). The mortality rate among HIV-positive IDUs was 13.4 per 100 person-years (95% CI = 5.4 -27.6). In a marginal Cox proportional-hazards model for clustered data, the excess mortality was associated with HIV-positivity (hazard ratio [HR] = 7.0, 95% CI = 2.8 -17.6), benzodiazepine use (HR = 3.1, 95% CI = 1.1-9.4), and excessive alcohol consumption at enrollment (HR = 3.5, 95% CI = 1.3-9.1). Conclusions: The all-cause mortality among the drug injectors is high. The increased mortality was associated with HIV infection, benzodiazepine use, and excessive alcohol consumption. © 2010 American Society of Addiction Medicine.
format Journal
author Quan V.
Aramrattana A.
Vongchak T.
Latkin C.
Donnell D.
Liu T.
Wiboonnatakul K.
Celentano D.
spellingShingle Quan V.
Aramrattana A.
Vongchak T.
Latkin C.
Donnell D.
Liu T.
Wiboonnatakul K.
Celentano D.
Mortality among injection drug users in northern thailand: A prospective cohort study
author_facet Quan V.
Aramrattana A.
Vongchak T.
Latkin C.
Donnell D.
Liu T.
Wiboonnatakul K.
Celentano D.
author_sort Quan V.
title Mortality among injection drug users in northern thailand: A prospective cohort study
title_short Mortality among injection drug users in northern thailand: A prospective cohort study
title_full Mortality among injection drug users in northern thailand: A prospective cohort study
title_fullStr Mortality among injection drug users in northern thailand: A prospective cohort study
title_full_unstemmed Mortality among injection drug users in northern thailand: A prospective cohort study
title_sort mortality among injection drug users in northern thailand: a prospective cohort study
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79551618877&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43181
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