Toxicity evaluation of sappan wood extract in rats

Background: The heartwood of Caesalpinia sappan L. or sappan wood has long been used in folk medicines to treat tuberculosis, diarrhea, dysentery, skin infections and anemia. Objective: To study the acute and subacute toxicities of sappan wood extract in rats. Material and Method: For studying acute...

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Main Authors: Sireeratawon S., Piyabha P., Singhala T., Wongkrajan Y., Temsiririrkku R., Punsrira J., Ruangwise N., Saray S., Lerdvuthisopo N., Jaijo K.
Format: Journal
Published: 2017
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952529032&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43185
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-431852017-09-28T06:51:41Z Toxicity evaluation of sappan wood extract in rats Sireeratawon S. Piyabha P. Singhala T. Wongkrajan Y. Temsiririrkku R. Punsrira J. Ruangwise N. Saray S. Lerdvuthisopo N. Jaijo K. Background: The heartwood of Caesalpinia sappan L. or sappan wood has long been used in folk medicines to treat tuberculosis, diarrhea, dysentery, skin infections and anemia. Objective: To study the acute and subacute toxicities of sappan wood extract in rats. Material and Method: For studying acute toxicity, a single oral dose of 5,000 mg/kg of sappan wood was administered to rats. Subacute toxicity was studied by the daily oral administration of the extract at the doses of 250, 500 and 1,000 mg/kg body weight for consecutive 30 days. Results: The extract of sappan wood (5,000 mg/kg) showed no toxicity in terms of general behavior change, mortality, or cha nge in gross appearance of internal organs. Subacute toxicity study showed no abnormalities in treatment groups as compared to the controls. Body and organ weights, hematological, blood chemical, necropsy, and histopathological parameter of all groups were similar. Conclusion: Sappan wood extract did not produce any acute or subacute toxicity in both female and male rats. 2017-09-28T06:51:41Z 2017-09-28T06:51:41Z 2010-12-01 Journal 01252208 2-s2.0-79952529032 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952529032&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43185
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Background: The heartwood of Caesalpinia sappan L. or sappan wood has long been used in folk medicines to treat tuberculosis, diarrhea, dysentery, skin infections and anemia. Objective: To study the acute and subacute toxicities of sappan wood extract in rats. Material and Method: For studying acute toxicity, a single oral dose of 5,000 mg/kg of sappan wood was administered to rats. Subacute toxicity was studied by the daily oral administration of the extract at the doses of 250, 500 and 1,000 mg/kg body weight for consecutive 30 days. Results: The extract of sappan wood (5,000 mg/kg) showed no toxicity in terms of general behavior change, mortality, or cha nge in gross appearance of internal organs. Subacute toxicity study showed no abnormalities in treatment groups as compared to the controls. Body and organ weights, hematological, blood chemical, necropsy, and histopathological parameter of all groups were similar. Conclusion: Sappan wood extract did not produce any acute or subacute toxicity in both female and male rats.
format Journal
author Sireeratawon S.
Piyabha P.
Singhala T.
Wongkrajan Y.
Temsiririrkku R.
Punsrira J.
Ruangwise N.
Saray S.
Lerdvuthisopo N.
Jaijo K.
spellingShingle Sireeratawon S.
Piyabha P.
Singhala T.
Wongkrajan Y.
Temsiririrkku R.
Punsrira J.
Ruangwise N.
Saray S.
Lerdvuthisopo N.
Jaijo K.
Toxicity evaluation of sappan wood extract in rats
author_facet Sireeratawon S.
Piyabha P.
Singhala T.
Wongkrajan Y.
Temsiririrkku R.
Punsrira J.
Ruangwise N.
Saray S.
Lerdvuthisopo N.
Jaijo K.
author_sort Sireeratawon S.
title Toxicity evaluation of sappan wood extract in rats
title_short Toxicity evaluation of sappan wood extract in rats
title_full Toxicity evaluation of sappan wood extract in rats
title_fullStr Toxicity evaluation of sappan wood extract in rats
title_full_unstemmed Toxicity evaluation of sappan wood extract in rats
title_sort toxicity evaluation of sappan wood extract in rats
publishDate 2017
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952529032&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43185
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