In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum

© 2017 Springer-Verlag London Ltd., part of Springer Nature Irritable bowel syndrome (IBS) is a symptom of functional gastrointestinal disorders. It is commonly experienced as abdominal cramp, diarrhea, and constipation. The diagnosis and treatment of IBS were mostly conducted by synthetic medicines...

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Main Authors: Chattida Wiya, Kanokporn Saenphet, Supap Saenphet, Wararut Buncharoen
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033477467&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43480
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spelling th-cmuir.6653943832-434802018-01-24T03:49:06Z In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum Chattida Wiya Kanokporn Saenphet Supap Saenphet Wararut Buncharoen © 2017 Springer-Verlag London Ltd., part of Springer Nature Irritable bowel syndrome (IBS) is a symptom of functional gastrointestinal disorders. It is commonly experienced as abdominal cramp, diarrhea, and constipation. The diagnosis and treatment of IBS were mostly conducted by synthetic medicines including antispasmodic drugs that have many side effects and are so expensive. The aim of the present study was to explore the antispasmodic activity of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair extracts on isolated rats’ ilia which later compared to atropine as reference drug. The ethanolic extracts from the stem of A. dulcis and U. rufa were investigated for their antispasmodic activities against acetylcholine-induced rats’ ilia contraction in vitro experiment. The results of this study showed that both ethanolic extracts of U. rufa and A. dulcis have an antispasmodic efficiency at all concentrations of 200, 300, 400, and 500 μg/ml on excised rats’ ilia. They produced the highest relaxation of 92.71 ± 5.97 and 98.53 ± 0.61% in A. dulcis and U. rufa extracts, respectively, while atropine produced 112.84 ± 5.61% at concentration of 10.0 μg/ml. These results suggest that U. rufa and A. dulcis could be used as antispasmodic agents for IBS treatment. 2018-01-24T03:49:06Z 2018-01-24T03:49:06Z 2017-11-09 Journal 1618565X 16185641 2-s2.0-85033477467 10.1007/s00580-017-2588-y https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033477467&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43480
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2017 Springer-Verlag London Ltd., part of Springer Nature Irritable bowel syndrome (IBS) is a symptom of functional gastrointestinal disorders. It is commonly experienced as abdominal cramp, diarrhea, and constipation. The diagnosis and treatment of IBS were mostly conducted by synthetic medicines including antispasmodic drugs that have many side effects and are so expensive. The aim of the present study was to explore the antispasmodic activity of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair extracts on isolated rats’ ilia which later compared to atropine as reference drug. The ethanolic extracts from the stem of A. dulcis and U. rufa were investigated for their antispasmodic activities against acetylcholine-induced rats’ ilia contraction in vitro experiment. The results of this study showed that both ethanolic extracts of U. rufa and A. dulcis have an antispasmodic efficiency at all concentrations of 200, 300, 400, and 500 μg/ml on excised rats’ ilia. They produced the highest relaxation of 92.71 ± 5.97 and 98.53 ± 0.61% in A. dulcis and U. rufa extracts, respectively, while atropine produced 112.84 ± 5.61% at concentration of 10.0 μg/ml. These results suggest that U. rufa and A. dulcis could be used as antispasmodic agents for IBS treatment.
format Journal
author Chattida Wiya
Kanokporn Saenphet
Supap Saenphet
Wararut Buncharoen
spellingShingle Chattida Wiya
Kanokporn Saenphet
Supap Saenphet
Wararut Buncharoen
In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum
author_facet Chattida Wiya
Kanokporn Saenphet
Supap Saenphet
Wararut Buncharoen
author_sort Chattida Wiya
title In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum
title_short In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum
title_full In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum
title_fullStr In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum
title_full_unstemmed In vitro analysis of antispasmodic activity of ethanolic stem extracts of Uvaria rufa Blume and Anomianthus dulcis (Dunal) J. Sinclair on excised rat’s ileum
title_sort in vitro analysis of antispasmodic activity of ethanolic stem extracts of uvaria rufa blume and anomianthus dulcis (dunal) j. sinclair on excised rat’s ileum
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85033477467&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43480
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