Fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease

© 2017 John Wiley & Sons, Ltd. Objective: To determine whether fetal isovolumetric time intervals can be an early sonographic marker of fetal anemia in fetuses with homozygous alpha thalassemia-1. Methods: Pregnancies at risk for fetal homozygous alpha thalassemia-1 disease at 18–22 weeks were...

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Main Authors: Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Kuntharee Traisrisilp, Phudit Jatavan, Theera Tongsong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/43597
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spelling th-cmuir.6653943832-435972018-04-25T07:37:35Z Fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease Fuanglada Tongprasert Kasemsri Srisupundit Suchaya Luewan Kuntharee Traisrisilp Phudit Jatavan Theera Tongsong Agricultural and Biological Sciences Arts and Humanities © 2017 John Wiley & Sons, Ltd. Objective: To determine whether fetal isovolumetric time intervals can be an early sonographic marker of fetal anemia in fetuses with homozygous alpha thalassemia-1. Methods: Pregnancies at risk for fetal homozygous alpha thalassemia-1 disease at 18–22 weeks were recruited before cordocentesis for hemoglobin typing. Isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) intervals were measured by placing pulsed wave Doppler sample volume within the left ventricle to obtain the mitral and aortic waveform. Time intervals were compared between the affected group of homozygous alpha thalassemia-1 fetuses and the unaffected group. Results: Among 70 fetuses at risk, 28 cases were diagnosed as affected by homozygous alpha thalassemia-1 disease. Mean ICT and ICT + IRT intervals in the affected group were significantly longer than in the unaffected group (47.9 ± 12.5 ms vs 35.0 ± 6.7 ms, p  <  0.001; and 96.2 ± 13.6 ms vs 80.9 ± 10.6 ms, p  <  0.001. ICT effectively predicted affected fetuses with 71.4% sensitivity and 78.6% specificity using a cutoff value ≥40 ms. Conclusions: Isovolumetric contraction time was significantly prolonged in fetal anemia from homozygous alpha thalassemia-1 during the early stage of hydropic changes. Because of its simple measurement and high efficacy, ICT can be a useful marker for prenatal screening of abnormal cardiac function in fetal anemia. © 2017 John Wiley & Sons, Ltd. 2018-01-24T03:50:33Z 2018-01-24T03:50:33Z 2017-10-01 Journal 10970223 01973851 2-s2.0-85029106393 10.1002/pd.5140 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029106393&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43597
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
Arts and Humanities
spellingShingle Agricultural and Biological Sciences
Arts and Humanities
Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Kuntharee Traisrisilp
Phudit Jatavan
Theera Tongsong
Fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease
description © 2017 John Wiley & Sons, Ltd. Objective: To determine whether fetal isovolumetric time intervals can be an early sonographic marker of fetal anemia in fetuses with homozygous alpha thalassemia-1. Methods: Pregnancies at risk for fetal homozygous alpha thalassemia-1 disease at 18–22 weeks were recruited before cordocentesis for hemoglobin typing. Isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) intervals were measured by placing pulsed wave Doppler sample volume within the left ventricle to obtain the mitral and aortic waveform. Time intervals were compared between the affected group of homozygous alpha thalassemia-1 fetuses and the unaffected group. Results: Among 70 fetuses at risk, 28 cases were diagnosed as affected by homozygous alpha thalassemia-1 disease. Mean ICT and ICT + IRT intervals in the affected group were significantly longer than in the unaffected group (47.9 ± 12.5 ms vs 35.0 ± 6.7 ms, p  <  0.001; and 96.2 ± 13.6 ms vs 80.9 ± 10.6 ms, p  <  0.001. ICT effectively predicted affected fetuses with 71.4% sensitivity and 78.6% specificity using a cutoff value ≥40 ms. Conclusions: Isovolumetric contraction time was significantly prolonged in fetal anemia from homozygous alpha thalassemia-1 during the early stage of hydropic changes. Because of its simple measurement and high efficacy, ICT can be a useful marker for prenatal screening of abnormal cardiac function in fetal anemia. © 2017 John Wiley & Sons, Ltd.
format Journal
author Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Kuntharee Traisrisilp
Phudit Jatavan
Theera Tongsong
author_facet Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Kuntharee Traisrisilp
Phudit Jatavan
Theera Tongsong
author_sort Fuanglada Tongprasert
title Fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease
title_short Fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease
title_full Fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease
title_fullStr Fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease
title_full_unstemmed Fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease
title_sort fetal isovolumetric time intervals as a marker of abnormal cardiac function in fetal anemia from homozygous alpha thalassemia-1 disease
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029106393&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/43597
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